QuickView for Esr1 (gene)

Gene Symbol:

ESR1 Homo sapiens

Full name:

estrogen receptor 1

Synonyms:

ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor, E2 receptor alpha, ER-alpha, estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha

Genomic Location:

Chr 6: 152170379-152466099

Description:

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual dev...

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This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  TTTGCAC_MIR19A_MIR19B ,  TGANTCA_AP1_C ,  CEBPA_01 ,  AAAGGGA_MIR204_MIR211 ,  RSRFC4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGANNYRGCA_TCF11MAFG_01 ,  GATA3_01 ,  AAANWWTGC_UNKNOWN ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  RSRFC4_Q2 ,  CEBP_Q2_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  SREBP1_Q6 ,  TTF1_Q6 ,  NKX22_01 ,  CTAWWWATA_RSRFC4_Q2 ,  TAAWWATAG_RSRFC4_Q2 ,  ATAGGAA_MIR202 ,  GGGAGGRR_MAZ_Q6 ,  MEF2_02 ,  GCACCTT_MIR18A_MIR18B ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TTCYRGAA_UNKNOWN ,  GR_Q6 ,  GACAATC_MIR219 ,  AAGGGAT_MIR188 ,  CEBPB_02 ,  IRF_Q6 ,  TGCCAAR_NF1_Q6 ,  TGTTTGY_HNF3_Q6 ,  NCX_01 ,  GGCAGCT_MIR22 ,  WGGAATGY_TEF1_Q6 ,  AFP1_Q6 ,  RTTTNNNYTGGM_UNKNOWN ,  ARGGGTTAA_UNKNOWN ,  MEF2_03 ,  IRF7_01 ,  TGCTTTG_MIR330 ,  AGGGCAG_MIR18A ,  TGATTTRY_GFI1_01 ,  AAGCACT_MIR520F ,  ICSBP_Q6 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  MMEF2_Q6 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  STTTCRNTTT_IRF_Q6 ,  IRF2_01 ,  ATGTAGC_MIR221_MIR222 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-496

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miRNA binding sites
(Source: miRecords):

hsa-miR-22 Targeted Genes

Cytogenetic Map:

6q25.1-q25.2

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