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QuickView for Ethopropazine (compound)


PubChem
Name: profenamine
PubChem Compound ID: 122824
Molecular formula: C19H25ClN2S
Molecular weight: 348.934 g/mol
Synonyms:
1094-08-2; 10-Phenothiazineethylamine, N,N-diethyl-alpha-methyl-, hydrochloride; Lysivane; Parkin (TN); EINECS 214-134-4; NSC 64074; Ethopropazine hydrochloride; Prestwick_195; Parsidol (TN); l-10-(2-Diethylaminopropyl)phenothiazine hydrochloride.
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DrugBank
Identification
Name: profenamine
Name (isomeric): DB00392
Drug Type: small molecule
Synonyms:
Athapropazine; Phenoprozine; Aethopropropazin; Phenopropazine; Ethopropazine Hydrochloride; Profenaminum [INN-Latin]; Etopropezina; Athopropazin; Isotazin; Profenamina [Italian].
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Brand: Parphezein, Parkisol, Lysivane, Rocipel, Parsidan, Pardidol, Rochipel, Prodictazin, Parfezine, Dibutil, Parcidol, Parsotil, Parphezin, Parfezin, Tomil, Rodipal, Parsitan, Parkin, Pardisol, Parsidol
Category: Antidyskinetics, Antiparkinson Agents
CAS number: 1094-08-2
Pharmacology
Indication: For use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine.
Pharmacology:
Ethopropazine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease. By improving muscle control and reducing stiffness, this drug permits more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines such as reserpine, phenothiazines, chlorprot...
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Mechanism of Action:
Ethopropazine's antiparkinson action can be attributed to its anticholinergic properties. Ethopropazine partially blocks central (striatal) cholinergic receptors, thereby helping to balance cholinergic and dopaminergic activity in the basal ganglia; salivation may be decreased, and smooth muscle may be relaxed. Drug-induced extrapyramidal symptoms ...
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Absorption: Well-absorbed from the gastrointestinal tract.
Protein binding: 93%
Half Life: 1 to 2 hours
Toxicity: Symptoms of overdose include severe clumsiness or unsteadiness, severe drowsiness, severe dryness of mouth, nose, or throat, fast heartbeat, shortness of breath or troubled breathing, and warmth, dryness, and flushing of skin.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
BromocriptineThe phenothiazine decreases the effect of bromocriptine
FenfluramineDecreased anorexic effect, may increase psychotic symptoms
DonepezilPossible antagonism of action
GuanethidineEthopropazine may decrease the effect of guanethidine.
HaloperidolThe anticholinergic increases the risk of psychosis and tardive dyskinesia
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Targets


Enzymes