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QuickView for Etidronic acid (compound)

Name: Etidronic Acid
PubChem Compound ID: 23894
Description: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Molecular formula: C2H6Na2O7P2
Molecular weight: 249.992 g/mol
7414-83-7; Diphos; Prestwick_1061; Etidronate disodium; Disodium ethane-1-hydroxy-1,1-diphosphonate; D00314; Didronel (TN); 1-HYDROXYETHANE-1,1-DIPHOSPHONATE, DISODIUM SALT; Disodium 1-hydroxyethylidene phosphonate; Disodium ethanol-1,1-diphosphonate.
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Name: Etidronic Acid
Name (isomeric): DB01077
Drug Type: small molecule
Description: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Acidum etidronicum [INN-Latin]; Acide etidronique [INN-French]; Etidronsaeure; Acetodiphosphonic acid; Oxyethylidenediphosphonic acid; HEDP; Acido etidronico [INN-Spanish]; Etidronate Disodium; Etidronate; Hydroxyethanediphosphonic acid.
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Brand: Didronel, Cintichem Technetium 99m Hedspa, Dequest 2015, Osteoscan, Didronel IV, Turpinal SL, Dequest 2010, MPI Stannous Diphosphonate, Ferrofos 510, Dequest Z 010
Brand name mixture: Didrocal(Etidronate Disodium + Calcium Carbonate)
Category: Antihypocalcemic Agents, Osteoporosis Prophylactic, Bisphosphonates, Antineoplastic Agents, Bone Density Conservation Agents
CAS number: 7414-83-7
Indication: For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
Etidronic acid is a first generation (non-nitrogenous) bisphosphonate in the same family as clodronate and tiludronate. Etidronic acid affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the etidronic acid that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchang...
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Mechanism of Action:
Bisphosphonates, when attached to bone tissue, are absorbed by osteoclasts, the bone cells that breaks down bone tissue. Although the mechanism of action of non-nitrogenous bisphosphonates has not been fully elucidated, available data suggest that they bind strongly to hydroxyapatite crystals in the bone matrix, preferentially at the sites of incre...
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Absorption: The amount of drug absorbed after an oral dose is approximately 3%.
Biotransformation: Not metabolized.
Route of elimination: Etidronate disodium is not metabolized. Within 24 hours, approximately half the absorbed dose is excreted in urine; the remainder is distributed to bone compartments from which it is slowly eliminated. Unabsorbed drug is excreted intact in the feces.
Half Life: In normal subjects, plasma half-life of etidronic acid, based on non-compartmental pharmacokinetics is 1 to 6 hours.
Toxicity: Clinical experience with acute etidronic acid overdosage is extremely limited. Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients. Some patients may develop vomiting. In one event, an 18-year-old female who ingested an estimated single dose of 4800 to 6000 mg (67 to 100 mg/kg) of etidronate was reported to be mildly hypocalcemic (7 .5 2 mg/ dl) and experienced paresthesia of the fingers.
Affected organisms: Humans and other mammals
Food interaction:
Avoid aluminium, calcium, iron and magnesium within 2 hours of taking medication.
Take on an empty stomach with a full glass of water.
Drug interaction:
MagnesiumFormation of non-absorbable complexes
AluminiumFormation of non-absorbable complexes
Iron DextranFormation of non-absorbable complexes
IronFormation of non-absorbable complexes
Calcium AcetateCalcium Salts may decrease the serum concentration of Bisphosphonate Derivatives such as etidronic acid (etidronate). Avoid administration of oral calcium supplements within 2 hours before or after tiludronate/clodronate/etidronate.
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