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QuickView for Ets-1 (gene)


Gene Symbol:
ETS1 Homo sapiens Homo sapiens
Full name:
ETS proto-oncogene 1, transcription factor
Synonyms:
ETS-1, EWSR2, c-ets-1, p54, protein C-ets-1, Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1, v-ets avian erythroblastosis virus E2 oncogene homolog 1, v-ets avian erythroblastosis virus E26 oncogene homolog 1
Genomic Location:
Chr 11: 127833870-127897371
Description:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 CTTGTAT_MIR381 RTAAACA_FREAC2_01 ACTGTAG_MIR139 STAT4_01 PR_02 TTANTCA_UNKNOWN RYTTCCTG_ETS2_B TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D PR_01
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-1 Predicted Gene Targets for miR-101 Predicted Gene Targets for miR-125 Predicted Gene Targets for miR-129 Predicted Gene Targets for miR-139 Predicted Gene Targets for miR-144 Predicted Gene Targets for miR-145 Predicted Gene Targets for miR-181 Predicted Gene Targets for miR-193 Predicted Gene Targets for miR-199
Cytogenetic Map:
chr 11
11q24.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | histone acetyltransferase binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | positive regulation of erythrocyte differentiation | brain development | nucleus organization | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | positive regulation of leukocyte adhesion to vascular endothelial cell | response to cytokine | response to interleukin-1 | cell motility | regulation of localization | regulation of immune system process | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | pri-miRNA transcription by RNA polymerase II | cell differentiation | nervous system development | response to drug | regulation of extracellular matrix organization | positive regulation of cell adhesion | positive regulation of cellular component movement | response to antibiotic | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | negative regulation of inflammatory response | regulation of cell motility | localization | response to estradiol | female pregnancy | multicellular organismal reproductive process | response to hypoxia | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | diencephalon development | response to inorganic substance | regulation of cell differentiation | response to hydrogen peroxide | regulation of angiogenesis | regulation of cellular process | regulation of metabolic process | pituitary gland development | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | positive regulation of epithelial cell migration | head development | regulation of vasculature development | response to stimulus | vasculature development | regulation of extracellular matrix disassembly | positive regulation of immune system process | response to stress | hypothalamus development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ovulation cycle | response to laminar fluid shear stress | tube morphogenesis | positive regulation of cell-cell adhesion | reproduction | cardiovascular system development | rhythmic process | cellular nitrogen compound metabolic process | cellular response to toxic substance | positive regulation of blood vessel endothelial cell migration | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | regulation of cell adhesion | cellular biosynthetic process | blood vessel development | regulation of nucleic acid-templated transcription | locomotion | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | cellular response to antibiotic | multicellular organism development | positive regulation of inflammatory response | cellular response to oxidative stress | wound healing | regulation of gene expression | cellular response to stress | response to lipid | positive regulation of cellular metabolic process | PML body organization | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to oxidative stress | positive regulation of cell differentiation | regulation of endothelial cell migration | positive regulation of myeloid cell differentiation | positive regulation of cell migration | biosynthetic process | aromatic compound biosynthetic process | angiogenesis | response to toxic substance | endocrine system development | cellular response to drug | regulation of cellular metabolic process | limbic system development | positive regulation of cell proliferation | regulation of locomotion | regulation of RNA metabolic process | multicellular organism reproduction | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | gland development | regulation of hemopoiesis | response to wounding | response to mechanical stimulus | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | regulation of erythrocyte differentiation | cellular response to hydrogen peroxide | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | animal organ development | response to reactive oxygen species | forebrain development | gene expression | nuclear body organization | transcription, DNA-templated | positive regulation of endothelial cell migration | angiogenesis involved in wound healing | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | estrous cycle | response to fluid shear stress | regulation of blood vessel endothelial cell migration | regulation of transcription, DNA-templated | response to organic cyclic compound | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | organelle organization | tube development | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | immune system process | cellular metabolic process | positive regulation of cell motility | circulatory system development | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular