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QuickView for F2 (gene)


Gene Symbol:
F2 Homo sapiens Homo sapiens
Full name:
coagulation factor II, thrombin
Synonyms:
PT, RPRGL2, THPH1, prothrombin, prepro-coagulation factor II, prothrombin B-chain, serine protease
Genomic Location:
Chr 11: 46697331-46717631
Description:
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 11
11p11.2





GO Molecular Function

enzyme activator activity | cation binding | thrombospondin receptor activity | lipid binding | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | molecular function regulator | catalytic activity | serine hydrolase activity | anion binding | signaling receptor activity | ion binding | heparin binding | protein binding | receptor regulator activity | growth factor activity | lipopolysaccharide binding | receptor ligand activity | glycosaminoglycan binding | serine-type endopeptidase activity | serine-type peptidase activity | calcium ion binding | endopeptidase activity | enzyme regulator activity | metal ion binding | peptidase activity

GO Biological Process

positive regulation of release of sequestered calcium ion into cytosol | negative regulation of cytokine production involved in inflammatory response | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cellular localization | enzyme activator activity | neutrophil mediated killing of bacterium | proteolysis | regulation of cell development | regulation of localization | positive regulation of collagen metabolic process | defense response to other organism | establishment of localization | regulation of immune system process | regulation of cell shape | negative regulation of cellular process | negative regulation of astrocyte differentiation | cell differentiation | defense response | nervous system development | cellular chemical homeostasis | killing by host of symbiont cells | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | intracellular transport | defense response to Gram-negative bacterium | negative regulation of proteolysis | interaction with symbiont | cellular process | negative regulation of gliogenesis | negative regulation of inflammatory response | localization | cellular homeostasis | positive regulation of blood coagulation | positive regulation of reactive oxygen species metabolic process | hemostasis | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of cell differentiation | interspecies interaction between organisms | regulation of platelet activation | cytolysis by host of symbiont cells | negative regulation of wound healing | regulation of immune response | regulation of cellular process | positive regulation of cell growth | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway | regulation of metabolic process | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | calcium ion homeostasis | response to stimulus | regulation of cellular protein localization | blood coagulation, intrinsic pathway | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | positive regulation of cation transmembrane transport | positive regulation of JAK-STAT cascade | positive regulation of cellular protein localization | regulation of cell proliferation | regulation of humoral immune response | cellular localization | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of wound healing | regulation of protein processing | molecular function regulator | metal ion homeostasis | blood coagulation | regulation of calcium ion transport into cytosol | response to external biotic stimulus | system development | positive regulation of response to wounding | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of calcium ion transmembrane transport | multicellular organism development | regulation of collagen biosynthetic process | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | wound healing | regulation of acute inflammatory response | blood coagulation, fibrin clot formation | regulation of gene expression | cell killing | platelet activation | modification of morphology or physiology of other organism | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of ion transmembrane transport | regulation of protein localization to nucleus | regulation of blood coagulation | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | vesicle-mediated transport | acute-phase response | regulation of release of sequestered calcium ion into cytosol | regulation of cytokine production involved in inflammatory response | cytolysis in other organism | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | regulation of calcium ion transmembrane transport | protein activation cascade | regulation of complement activation | cation homeostasis | fibrinolysis | negative regulation of response to wounding | response to bacterium | regulation of lipid kinase activity | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | antimicrobial humoral immune response mediated by antimicrobial peptide | negative regulation of cell activation | humoral immune response | inflammatory response | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | Golgi vesicle transport | positive regulation of transport | coagulation | positive regulation of molecular function | disruption by host of symbiont cells | regulation of signaling receptor activity | antimicrobial humoral response | receptor regulator activity | protein metabolic process | positive regulation of protein modification process | regulation of growth | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | killing of cells of other organism | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | metabolic process | regulation of body fluid levels | positive regulation of coagulation | chemical homeostasis | receptor ligand activity | immune response | leukocyte mediated cytotoxicity | organic substance metabolic process | regulation of sequestering of calcium ion | positive regulation of ion transport | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | ion homeostasis | serine-type endopeptidase activity | regulation of phosphate metabolic process | positive regulation of wound healing | regulation of ion transmembrane transport | serine-type peptidase activity | cell activation | negative regulation of protein metabolic process | regulation of glial cell differentiation | regulation of response to wounding | regulation of cell communication | regulation of gliogenesis | ER to Golgi vesicle-mediated transport | signaling | positive regulation of growth | endopeptidase activity | regulation of fibrinolysis | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | developmental process | regulation of cell growth | neutrophil mediated killing of gram-negative bacterium | regulation of calcium ion transport | negative regulation of glial cell differentiation | negative regulation of coagulation | regulation of transport | regulation of reactive oxygen species metabolic process | positive regulation of lipid kinase activity | neutrophil mediated immunity | cytolysis | cellular metal ion homeostasis | cytolysis in other organism involved in symbiotic interaction | negative regulation of blood coagulation | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | acute inflammatory response | immune system process | positive regulation of collagen biosynthetic process | cellular metabolic process | negative regulation of platelet activation | peptidase activity | negative regulation of fibrinolysis | regulation of protein localization | regulation of astrocyte differentiation | negative regulation of cell development | regulation of inflammatory response | divalent inorganic cation homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of calcium ion transport | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | external side of plasma membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | endomembrane system | plasma membrane | vesicle | endoplasmic reticulum lumen | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane-enclosed lumen | blood microparticle | cell surface | intracellular | membrane | Golgi lumen