QuickView for F2R (gene)
- Gene Symbol:
- F2R
Homo sapiens - Full name:
- coagulation factor II thrombin receptor
- Synonyms:
- CF2R, HTR, PAR-1, PAR1, TR, proteinase-activated receptor 1, protease-activated receptor 1
- Genomic Location:
- Chr 5: 76047542-76067054
- Description:
-
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q13.3
GO Molecular Function
transmembrane signaling receptor activity | G-protein coupled receptor activity | signaling receptor binding | thrombin-activated receptor activity | signaling receptor activity | protein binding | G-protein beta-subunit binding | peptide receptor activity | G-protein coupled peptide receptor activity | G-protein alpha-subunit binding
GO Biological Process
positive regulation of release of sequestered calcium ion into cytosol | regulation of ERK1 and ERK2 cascade | regulation of interleukin-1 beta production | regulation of blood vessel diameter | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | positive regulation of blood circulation | positive regulation of Ras protein signal transduction | response to lipopolysaccharide | regulation of cellular localization | negative regulation of peptide secretion | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | homeostasis of number of cells within a tissue | cytosolic calcium ion transport | regulation of localization | positive regulation of collagen metabolic process | regulation of programmed cell death | establishment of localization | negative regulation of neuron death | negative regulation of cellular process | regulation of MAP kinase activity | secretory granule organization | defense response | regulation of smooth muscle contraction | regulation of renin secretion into blood stream | cellular chemical homeostasis | positive regulation of phosphate metabolic process | negative regulation of protein secretion | positive regulation of cellular component movement | positive regulation of protein secretion | tissue homeostasis | regulation of neuron death | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | cellular homeostasis | tissue remodeling | metal ion transport | positive regulation of blood coagulation | positive regulation of protein kinase activity | hemostasis | negative regulation of apoptotic process | endomembrane system organization | negative regulation of secretion | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of establishment of protein localization | regulation of neurological system process | anatomical structure homeostasis | positive regulation of vasoconstriction | positive regulation of interleukin-8 production | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | cellular component organization | calcium ion homeostasis | G-protein coupled receptor activity | calcium ion transport into cytosol | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | regulation of interleukin-8 secretion | establishment of synaptic specificity at neuromuscular junction | positive regulation of protein metabolic process | positive regulation of peptidase activity | regulation of blood vessel size | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | positive regulation of cation transmembrane transport | positive regulation of JAK-STAT cascade | regulation of cell proliferation | multicellular organismal homeostasis | regulation of blood circulation | positive regulation of cysteine-type endopeptidase activity | cellular localization | divalent metal ion transport | positive regulation of cytokine secretion | positive regulation of proteolysis | response to molecule of bacterial origin | negative regulation of transport | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | regulation of wound healing | regulation of peptide transport | modulation of chemical synaptic transmission | cell-cell signaling | activation of protein kinase activity | metal ion homeostasis | blood coagulation | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | negative regulation of neuron apoptotic process | thrombin-activated receptor activity | regulation of calcium ion transport into cytosol | response to external biotic stimulus | positive regulation of response to wounding | regulation of signal transduction | negative regulation of secretion by cell | positive regulation of calcium ion transmembrane transport | regulation of peptidase activity | calcium ion transmembrane transport | inflammatory response to wounding | regulation of MAPK cascade | regulation of collagen biosynthetic process | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | negative regulation of glomerular filtration | regulation of phosphorylation | ion transmembrane transport | regulation of sensory perception of pain | connective tissue replacement involved in inflammatory response wound healing | wound healing | regulation of small GTPase mediated signal transduction | regulation of gene expression | platelet activation | positive regulation of secretion | response to lipid | regulation of blood pressure | synaptic signaling | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | neuromuscular junction development | cellular ion homeostasis | positive regulation of ion transmembrane transport | regulation of blood coagulation | positive regulation of cytosolic calcium ion concentration | positive regulation of Rho protein signal transduction | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | regulation of cellular component movement | synapse organization | positive regulation of hydrolase activity | regulation of release of sequestered calcium ion into cytosol | homeostasis of number of cells | positive regulation of cell migration | regulation of Rho protein signal transduction | regulation of glomerular filtration | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | positive regulation of endopeptidase activity | regulation of calcium ion transmembrane transport | regulation of GTPase activity | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | response to bacterium | regulation of interleukin-1 production | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of smooth muscle contraction | regulation of neuron apoptotic process | inflammatory response | activation of MAPKK activity | regulation of endocrine process | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | protein kinase C-activating G-protein coupled receptor signaling pathway | regulation of locomotion | regulation of RNA metabolic process | regulation of tube size | positive regulation of transport | coagulation | wound healing involved in inflammatory response | positive regulation of molecular function | release of sequestered calcium ion into cytosol | regulation of cytokine secretion | cation transmembrane transport | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | anatomical structure development | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | positive regulation of small GTPase mediated signal transduction | regulation of vasoconstriction | cellular component maintenance | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of programmed cell death | positive regulation of coagulation | regulation of tube diameter | chemical homeostasis | calcium ion transport | regulation of secretion | positive regulation of cell death | positive regulation of interleukin-6 production | positive regulation of interleukin-8 secretion | positive regulation of muscle contraction | regulation of sequestering of calcium ion | negative regulation of renin secretion into blood stream | positive regulation of ion transport | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | platelet dense granule organization | thrombin-activated receptor signaling pathway | ion homeostasis | regulation of phosphate metabolic process | positive regulation of wound healing | inorganic cation transmembrane transport | regulation of ion transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | renal system process | vesicle organization | positive regulation of cytokine production | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | cell-cell junction maintenance | regulation of response to wounding | regulation of cell communication | transmembrane transport | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | G-protein coupled peptide receptor activity | regulation of transcription, DNA-templated | positive regulation of phosphorylation | regulation of cytokine production | regulation of Ras protein signal transduction | anatomical structure morphogenesis | regulation of endopeptidase activity | cation transport | positive regulation of MAP kinase activity | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | regulation of ion transport | renal system process involved in regulation of systemic arterial blood pressure | developmental process | organelle organization | regulation of calcium ion transport | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | cellular metal ion homeostasis | positive regulation of metabolic process | ion transport | positive regulation of collagen biosynthetic process | trans-synaptic signaling by endocannabinoid, modulating synaptic transmission | regulation of protein localization | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | regulation of interleukin-6 production | divalent inorganic cation homeostasis | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of calcium ion transport | response to other organism | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | positive regulation of interleukin-6 secretion | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | synapse | late endosome | neuromuscular junction | cytoplasmic vesicle | cell | intrinsic component of membrane | synaptic membrane | cytoplasm | intracellular organelle | membrane microdomain | Golgi apparatus | postsynaptic membrane | endomembrane system | postsynapse | plasma membrane | membrane raft | vesicle | integral component of plasma membrane | endosome | extracellular region | platelet dense tubular network | membrane-bounded organelle | organelle | cell periphery | early endosome | plasma membrane raft | intracellular vesicle | cell surface | intracellular | caveola | membrane | intrinsic component of plasma membrane
