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QuickView for FAF2;jsessionid=1DEB09148B9CC5FB567F5506DBDEC4A4 (gene)


Gene Symbol:
FAF2 Homo sapiens Homo sapiens
Full name:
Fas associated factor family member 2
Synonyms:
ETEA, UBXD8, UBXN3B, FAS-associated factor 2, UBX domain containing 8, UBX domain protein 3B, UBX domain-containing protein 3B, UBX domain-containing protein 8, expressed in T-cells and eosinophils in atopic dermatitis
Genomic Location:
Chr 5: 175807962-175869681
Description:
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5q35.2


Transcripts Names
NM_014613
XM_011534475
Protein Names
Q96CS3
Q9BRP2
O94963
Q9BVM7
Q8IUF2



GO Molecular Function

enzyme binding | enzyme inhibitor activity | ubiquitin binding | molecular function regulator | ubiquitin-like protein ligase binding | lipase inhibitor activity | ubiquitin-like protein binding | protein binding | lipase binding | ubiquitin protein ligase binding | enzyme regulator activity

GO Biological Process

response to endoplasmic reticulum stress | exocytosis | neutrophil activation | proteolysis | establishment of localization | intracellular transport | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | proteolysis involved in cellular protein catabolic process | protein transport | macromolecule localization | establishment of localization in cell | lipid droplet organization | leukocyte activation | catabolic process | response to topologically incorrect protein | cellular component organization | response to stimulus | enzyme inhibitor activity | neutrophil degranulation | response to stress | intracellular protein transport | leukocyte activation involved in immune response | cellular protein catabolic process | cellular localization | secretion by cell | proteasomal protein catabolic process | molecular function regulator | response to nitrogen compound | nitrogen compound metabolic process | negative regulation of catalytic activity | leukocyte mediated immunity | regulation of catalytic activity | organic substance transport | cellular response to stress | protein catabolic process | peptide transport | lipase inhibitor activity | vesicle-mediated transport | regulated exocytosis | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | proteasome-mediated ubiquitin-dependent protein catabolic process | ERAD pathway | protein metabolic process | response to organic substance | cellular macromolecule catabolic process | metabolic process | cellular protein localization | amide transport | immune response | organic substance metabolic process | establishment of protein localization | cell activation | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | negative regulation of molecular function | protein localization | cellular protein metabolic process | enzyme regulator activity | response to unfolded protein | cellular macromolecule localization | organelle organization | neutrophil mediated immunity | response to organonitrogen compound | ubiquitin-dependent ERAD pathway | immune system process | cellular metabolic process | modification-dependent protein catabolic process | protein exit from endoplasmic reticulum | retrograde protein transport, ER to cytosol | macromolecule metabolic process

GO Cellular Component

secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | secretory vesicle | endomembrane system | endoplasmic reticulum membrane | vacuole | vesicle | lipid droplet | lytic vacuole | extracellular region | membrane-bounded organelle | organelle | lysosome | VCP-NPL4-UFD1 AAA ATPase complex | membrane-enclosed lumen | azurophil granule | secretory granule lumen | intracellular vesicle | intracellular | membrane | vesicle lumen