QuickView for FBP1 (gene)
- Gene Symbol:
- FBP1
Homo sapiens - Full name:
- fructose-bisphosphatase 1
- Synonyms:
- FBP, fructose-1,6-bisphosphatase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, FBPase 1, growth-inhibiting protein 17, liver FBPase
- Genomic Location:
- Chr 9: 96405236-96441624
- Description:
-
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
9q22.32
GO Molecular Function
transcription factor activity, transcription factor binding | cation binding | transcription factor activity, RNA polymerase II transcription factor binding | ribonucleotide binding | nucleotide binding | phosphatase activity | transcriptional repressor activity, RNA polymerase II transcription factor binding | hydrolase activity | sugar-phosphatase activity | fructose 1,6-bisphosphate 1-phosphatase activity | carbohydrate derivative binding | monosaccharide binding | catalytic activity | anion binding | AMP binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | identical protein binding | ion binding | organic cyclic compound binding | carbohydrate binding | protein binding | phosphoric ester hydrolase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | carbohydrate phosphatase activity | small molecule binding
GO Biological Process
negative regulation of phosphorylation | protein homooligomerization | transcription factor activity, transcription factor binding | regulation of carbohydrate metabolic process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | response to metal ion | glucose metabolic process | response to drug | cellular process | disaccharide metabolic process | response to magnesium ion | regulation of glycolytic process | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | sucrose metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | response to inorganic substance | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | cellular component organization | negative regulation of nucleotide metabolic process | cellular response to metal ion | phosphatase activity | response to stimulus | transcriptional repressor activity, RNA polymerase II transcription factor binding | sugar-phosphatase activity | fructose 1,6-bisphosphate 1-phosphatase activity | cellular response to inorganic substance | negative regulation of metabolic process | cellular component assembly | fructose metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | regulation of signal transduction | negative regulation of growth | negative regulation of phosphate metabolic process | negative regulation of ATP metabolic process | phosphorus metabolic process | protein complex oligomerization | regulation of phosphorylation | regulation of small GTPase mediated signal transduction | regulation of gene expression | sucrose biosynthetic process | organophosphate metabolic process | hexose biosynthetic process | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | regulation of transcription by RNA polymerase II | protein homotetramerization | carbohydrate biosynthetic process | biosynthetic process | carbohydrate metabolic process | protein tetramerization | phosphate-containing compound metabolic process | cellular response to drug | regulation of cellular metabolic process | regulation of RNA metabolic process | negative regulation of cell growth | oligosaccharide metabolic process | protein-containing complex assembly | negative regulation of carbohydrate metabolic process | regulation of growth | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of glucose metabolic process | metabolic process | regulation of RNA biosynthetic process | hexose metabolic process | negative regulation of transcription, DNA-templated | gluconeogenesis | negative regulation of glycolytic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of small GTPase mediated signal transduction | negative regulation of Ras protein signal transduction | negative regulation of ATP biosynthetic process | regulation of ATP metabolic process | regulation of phosphate metabolic process | fructose 1,6-bisphosphate metabolic process | regulation of cell communication | dephosphorylation | negative regulation of signal transduction | regulation of transcription, DNA-templated | regulation of Ras protein signal transduction | regulation of cell growth | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | fructose 6-phosphate metabolic process | regulation of gluconeogenesis | regulation of generation of precursor metabolites and energy | cellular metabolic process | carbohydrate phosphatase activity | regulation of cellular component organization | oligosaccharide biosynthetic process | regulation of signaling | cellular response to magnesium ion | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | intracellular
