QuickView for FBXL3;jsessionid=546F649770729EDEECC87F580F6DE192 (gene)

Gene Symbol:

FBXL3 Homo sapiens

Full name:

F-box and leucine rich repeat protein 3

Synonyms:

FBL3, FBL3A, FBXL3A, F-box/LRR-repeat protein 3, F-box and leucine-rich repeat protein 3A, F-box protein Fbl3a, F-box/LRR-repeat protein 3A

Genomic Location:

Chr 13: 76477397-76499258

Description:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into ...

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTCTATG_MIR368 ,  CTATGCA_MIR153 ,  ACTTTAT_MIR1425P ,  STAT3_02 ,  ZID_01 ,  ACCAAAG_MIR9 ,  ATGTTAA_MIR302C ,  ATACTGT_MIR144

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

13q22.3

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