protein phosphorylated amino acid binding | cyclin binding | enzyme binding | ubiquitin-protein transferase activator activity | ubiquitin binding | molecular function regulator | catalytic activity | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | protein binding, bridging | identical protein binding | ubiquitin-like protein binding | molecular adaptor activity | phosphoprotein binding | protein binding | ubiquitin protein ligase binding | ubiquitin-protein transferase activity | transferase activity | enzyme regulator activity | ubiquitin-protein transferase regulator activity | phosphothreonine residue binding
regulation of ERK1 and ERK2 cascade | regulation of cell cycle process | regulation of intracellular protein transport | negative regulation of immune system process | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of cellular localization | positive regulation of apoptotic process | proteolysis | regulation of cell development | protein stabilization | regulation of localization | regulation of cell cycle G1/S phase transition | regulation of programmed cell death | negative regulation of bone development | positive regulation of peptidyl-tyrosine phosphorylation | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | positive regulation of signaling receptor activity | positive regulation of intrinsic apoptotic signaling pathway | positive regulation of protein catabolic process | negative regulation of osteoclast differentiation | positive regulation of phosphate metabolic process | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | regulation of neuron death | cellular process | organic substance catabolic process | positive regulation of epidermal growth factor-activated receptor activity | cellular homeostasis | proteolysis involved in cellular protein catabolic process | regulation of ubiquitin-protein transferase activity | negative regulation of signaling | positive regulation of protein kinase activity | negative regulation of lipid biosynthetic process | regulation of proteolysis | regulation of hepatocyte proliferation | regulation of cell cycle | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | interspecies interaction between organisms | regulation of cellular process | regulation of osteoclast development | regulation of apoptotic process | ubiquitin-protein transferase activator activity | regulation of metabolic process | catabolic process | positive regulation of cellular protein metabolic process | cellular component organization | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | negative regulation of DNA replication | positive regulation of cellular protein catabolic process | vasculature development | regulation of cellular protein localization | positive regulation of protein targeting to mitochondrion | regulation of peptidyl-tyrosine phosphorylation | chromosome segregation | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | positive regulation of cellular protein localization | regulation of cell proliferation | regulation of protein ubiquitination | regulation of cell cycle phase transition | positive regulation of proteolysis involved in cellular protein catabolic process | cellular protein catabolic process | cardiovascular system development | positive regulation of proteolysis | proteasomal protein catabolic process | regulation of protein transport | negative regulation of metabolic process | negative regulation of hemopoiesis | protein modification process | regulation of peptide transport | positive regulation of response to oxidative stress | regulation of triglyceride metabolic process | macromolecule modification | regulation of lipid storage | positive regulation of ERBB signaling pathway | regulation of intracellular transport | molecular function regulator | positive regulation of mitochondrion organization | negative regulation of triglyceride biosynthetic process | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of protein tyrosine kinase activity | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | multicellular organism development | regulation of MAPK cascade | sister chromatid segregation | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | regulation of catalytic activity | negative regulation of hepatocyte proliferation | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | regulation of gene expression | cell cycle | protein catabolic process | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of cellular response to oxidative stress | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of Notch signaling pathway | regulation of DNA endoreduplication | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | negative regulation of osteoclast development | regulation of cellular protein metabolic process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | positive regulation of proteasomal protein catabolic process | positive regulation of neuron death | regulation of apoptotic signaling pathway | regulation of DNA-dependent DNA replication | regulation of mitochondrion organization | nuclear chromosome segregation | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | negative regulation of DNA endoreduplication | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | positive regulation of oxidative stress-induced cell death | regulation of RNA metabolic process | positive regulation of transport | viral process | regulation of lipid biosynthetic process | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | regulation of autophagy of mitochondrion | positive regulation of molecular function | protein polyubiquitination | regulation of signaling receptor activity | regulation of epidermal growth factor-activated receptor activity | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | protein ubiquitination | negative regulation of DNA-dependent DNA replication | regulation of hemopoiesis | regulation of kinase activity | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | regulation of bone development | cellular macromolecule catabolic process | positive regulation of neuron apoptotic process | anatomical structure development | negative regulation of lipid metabolic process | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of protein targeting | regulation of RNA biosynthetic process | regulation of proteasomal protein catabolic process | chemical homeostasis | positive regulation of cell death | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | negative regulation of biosynthetic process | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | positive regulation of intracellular transport | positive regulation of MAPK cascade | positive regulation of protein transport | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | regulation of osteoclast differentiation | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | ubiquitin recycling | regulation of ERBB signaling pathway | regulation of epithelial cell proliferation | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | cellular protein metabolic process | enzyme regulator activity | positive regulation of epidermal growth factor receptor signaling pathway | regulation of developmental process | positive regulation of oxidative stress-induced neuron death | developmental process | organelle organization | ubiquitin-protein transferase regulator activity | negative regulation of SREBP signaling pathway | sister chromatid cohesion | cellular protein modification process | regulation of transport | negative regulation of cell proliferation | negative regulation of triglyceride metabolic process | positive regulation of ubiquitin-protein transferase activity | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | negative regulation of Notch signaling pathway | cellular metabolic process | negative regulation of cell cycle process | regulation of protein localization | regulation of cell death | modification-dependent protein catabolic process | negative regulation of cell development | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | positive regulation of protein ubiquitination | regulation of triglyceride biosynthetic process | negative regulation of myeloid leukocyte differentiation | lipid homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | positive regulation of signaling | regulation of signaling | post-translational protein modification | macromolecule metabolic process | multicellular organismal process | regulation of protein targeting to mitochondrion | regulation of phosphorus metabolic process
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | nucleoplasm | transferase complex | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | SCF ubiquitin ligase complex | Parkin-FBXW7-Cul1 ubiquitin ligase complex | cytosol | intracellular