Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for FDFT1;jsessionid=39A2EA10DF6587251E49AE65A487A927 (gene)

Gene Symbol:
FDFT1 Homo sapiens Homo sapiens
Full name:
farnesyl-diphosphate farnesyltransferase 1
DGPT, ERG9, SQS, SS, squalene synthase, FPP:FPP farnesyltransferase, presqualene-di-diphosphate synthase, squalene synthetase
Genomic Location:
Chr 8: 11697599-11734227
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Bos taurus Gallus gallus Canis lupus familiaris Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8

GO Molecular Function

farnesyl-diphosphate farnesyltransferase activity | transferase activity, transferring alkyl or aryl (other than methyl) groups | prenyltransferase activity | farnesyltranstransferase activity | catalytic activity | protein binding | transferase activity | squalene synthase activity

GO Biological Process

isoprenoid biosynthetic process | phospholipid metabolic process | sterol metabolic process | cellular process | regulation of metabolic process | organic cyclic compound metabolic process | steroid biosynthetic process | cellular lipid metabolic process | alcohol metabolic process | ergosterol biosynthetic process | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of steroid metabolic process | organic hydroxy compound metabolic process | phosphorus metabolic process | lipid metabolic process | regulation of cholesterol biosynthetic process | organophosphate metabolic process | sterol biosynthetic process | small molecule metabolic process | regulation of cholesterol metabolic process | biosynthetic process | cholesterol biosynthetic process | lipid biosynthetic process | phosphate-containing compound metabolic process | regulation of lipid biosynthetic process | metabolic process | cholesterol metabolic process | organic substance metabolic process | steroid metabolic process | farnesyl diphosphate metabolic process | isoprenoid metabolic process | regulation of lipid metabolic process | cellular metabolic process | ergosterol metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane