QuickView for FDFT1;jsessionid=39A2EA10DF6587251E49AE65A487A927 (gene)

Gene Symbol:

FDFT1 Homo sapiens

Full name:

farnesyl-diphosphate farnesyltransferase 1

Synonyms:

DGPT, ERG9, SQS, SS, squalene synthase, FPP:FPP farnesyltransferase, presqualene-di-diphosphate synthase, squalene synthetase

Genomic Location:

Chr 8: 11697599-11734227

Description:

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFY_C ,  NFY_Q6_01 ,  GGGCGGR_SP1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-539

Cytogenetic Map:

8p23.1

search → result