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QuickView for FGA (gene)


Gene Symbol:
FGA Homo sapiens Homo sapiens
Full name:
fibrinogen alpha chain
Synonyms:
Fib2, fibrinogen alpha chain, fibrinogen, A alpha polypeptide
Genomic Location:
Chr 4: 155723730-155731347
Description:
This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenem...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4
4q31.3


Transcripts Names
NM_000508
NM_021871



GO Molecular Function

structural molecule activity | cation binding | signaling receptor binding | ion binding | cell adhesion molecule binding | protein binding | metal ion binding

GO Biological Process

positive regulation of immune response | regulation of ERK1 and ERK2 cascade | adaptive immune response | regulation of blood vessel diameter | positive regulation of blood circulation | exocytosis | extracellular structure organization | positive regulation of cellular component organization | regulation of cell morphogenesis | immune response-regulating signaling pathway | proteolysis | regulation of cell development | regulation of localization | cell-substrate adhesion | regulation of programmed cell death | defense response to other organism | establishment of localization | regulation of immune system process | platelet degranulation | negative regulation of cellular process | positive regulation of developmental process | protein processing | response to metal ion | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of peptide hormone secretion | positive regulation of protein secretion | innate immune response-activating signal transduction | cellular process | secretion | toll-like receptor signaling pathway | localization | zymogen activation | negative regulation of signaling | positive regulation of heterotypic cell-cell adhesion | hemostasis | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | induction of bacterial agglutination | response to inorganic substance | regulation of cell differentiation | positive regulation of vasoconstriction | negative regulation of apoptotic signaling pathway | negative regulation of wound healing | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | platelet aggregation | regulation of peptide secretion | response to stimulus | negative regulation of epithelial cell apoptotic process | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of blood vessel size | response to stress | regulation of heterotypic cell-cell adhesion | regulation of blood circulation | positive regulation of cell-cell adhesion | activation of innate immune response | secretion by cell | positive regulation of hormone secretion | immune response-activating signal transduction | extracellular matrix organization | regulation of protein transport | blood circulation | cellular component assembly | regulation of wound healing | protein modification process | regulation of peptide transport | regulation of cell adhesion | macromolecule modification | blood coagulation | positive regulation of peptide secretion | positive regulation of exocytosis | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | antibacterial humoral response | regulation of MAPK cascade | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | wound healing | blood coagulation, fibrin clot formation | regulation of extrinsic apoptotic signaling pathway | platelet activation | blood coagulation, common pathway | positive regulation of secretion | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of blood coagulation | regulation of nitrogen compound metabolic process | regulation of cell-substrate adhesion | protein polymerization | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of endothelial cell apoptotic process | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | regulation of cellular protein metabolic process | regulated exocytosis | cellular protein-containing complex assembly | protein maturation | protein activation cascade | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | fibrinolysis | negative regulation of response to wounding | response to bacterium | cell communication | regulation of cellular metabolic process | humoral immune response | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of tube size | positive regulation of transport | positive regulation of peptide hormone secretion | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | coagulation | antimicrobial humoral response | protein-containing complex assembly | activation of immune response | regulation of cell morphogenesis involved in differentiation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of innate immune response | response to wounding | regulation of intracellular signal transduction | regulation of exocytosis | regulation of vasoconstriction | metabolic process | positive regulation of cell development | regulation of body fluid levels | negative regulation of programmed cell death | regulation of tube diameter | regulation of vesicle-mediated transport | regulation of secretion | cell adhesion | immune response | organic substance metabolic process | positive regulation of cell-substrate adhesion | gene expression | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | cell-cell adhesion | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of response to wounding | regulation of cell communication | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | cell-matrix adhesion | positive regulation of phosphorylation | cellular protein metabolic process | response to biotic stimulus | regulation of developmental process | cellular protein modification process | negative regulation of coagulation | regulation of transport | regulation of cell-cell adhesion | innate immune response | response to calcium ion | negative regulation of blood coagulation | plasminogen activation | positive regulation of metabolic process | immune system process | cellular metabolic process | regulation of protein localization | regulation of cell death | regulation of substrate adhesion-dependent cell spreading | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | positive regulation of substrate adhesion-dependent cell spreading | regulation of cellular component organization | homotypic cell-cell adhesion | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | post-translational protein modification | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | external side of plasma membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | platelet alpha granule | fibrinogen complex | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | vesicle | endoplasmic reticulum lumen | extracellular exosome | cytoplasmic region | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane-enclosed lumen | secretory granule lumen | blood microparticle | intracellular vesicle | cell surface | intracellular | membrane | platelet alpha granule lumen | vesicle lumen