QuickView for FGF1 (gene)
- Gene Symbol:
- FGF1
Homo sapiens - Full name:
- fibroblast growth factor 1
- Synonyms:
- AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1, beta-endothelial cell growth factor, endothelial cell growth factor, alpha, endothelial cell growth factor, beta, fibroblast growth factor 1 (acidic), heparin-binding growth factor 1
- Genomic Location:
- Chr 5: 141953306-142045812
- Description:
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q31.3
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | S100 protein binding | enzyme binding | protein-containing complex binding | signaling receptor binding | carbohydrate derivative binding | Ras GTPase binding | molecular function regulator | catalytic activity | Hsp70 protein binding | anion binding | phosphatidylinositol 3-kinase activity | fibroblast growth factor receptor binding | ion binding | integrin binding | heparin binding | cell adhesion molecule binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein tyrosine kinase activity | protein binding | receptor regulator activity | 1-phosphatidylinositol-3-kinase activity | growth factor activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | receptor ligand activity | protein kinase activity | glycosaminoglycan binding | transferase activity | small GTPase binding | growth factor receptor binding | kinase activity | heat shock protein binding
GO Biological Process
positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | guanyl-nucleotide exchange factor activity | intracellular signal transduction | regulation of localization | morphogenesis of an epithelium | peptidyl-amino acid modification | phosphatidylinositol metabolic process | positive regulation of developmental process | regulation of MAP kinase activity | cell differentiation | positive regulation of epithelial cell proliferation | respiratory tube development | regulation of sprouting angiogenesis | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular component movement | phosphatidylinositol-3-phosphate biosynthetic process | phospholipid metabolic process | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | epithelial tube morphogenesis | developmental growth | renal tubule morphogenesis | positive regulation of protein kinase activity | regulation of chemotaxis | branching involved in ureteric bud morphogenesis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | tissue development | regulation of angiogenesis | regulation of protein kinase B signaling | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | positive regulation of cholesterol biosynthetic process | cellular lipid metabolic process | MAPK cascade | regulation of cell division | urogenital system development | positive regulation of epithelial cell migration | nephron tubule morphogenesis | regulation of vasculature development | response to stimulus | vasculature development | respiratory system development | cellular response to fibroblast growth factor stimulus | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | regulation of cell proliferation | positive regulation of lipid biosynthetic process | tube morphogenesis | cardiovascular system development | response to temperature stimulus | positive regulation of sprouting angiogenesis | axis elongation | regulation of endothelial cell chemotaxis to fibroblast growth factor | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of steroid biosynthetic process | cellular biosynthetic process | branch elongation involved in ureteric bud branching | kidney development | macromolecule modification | regulation of steroid metabolic process | activation of protein kinase activity | molecular function regulator | blood vessel development | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | ureteric bud development | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | kidney morphogenesis | fibroblast growth factor receptor signaling pathway | regulation of cholesterol biosynthetic process | regulation of gene expression | kidney epithelium development | cellular response to stress | organophosphate metabolic process | cellular response to heat | regulation of endothelial tube morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | phospholipid biosynthetic process | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | regulation of transcription by RNA polymerase II | phosphatidylinositol 3-kinase activity | regulation of endothelial cell migration | activation of protein kinase B activity | regulation of cholesterol metabolic process | positive regulation of steroid metabolic process | positive regulation of cell migration | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | angiogenesis | phosphorylation | mesonephric epithelium development | lipid biosynthetic process | protein phosphorylation | mesonephros development | phosphate-containing compound metabolic process | lipid phosphorylation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | renal tubule development | regulation of protein metabolic process | positive regulation of signal transduction | lipid modification | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | renal system development | regulation of lipid biosynthetic process | regulation of cellular response to growth factor stimulus | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | nephron development | protein tyrosine kinase activity | positive regulation of molecular function | activation of MAPK activity | regulation of signaling receptor activity | receptor regulator activity | ureteric bud morphogenesis | protein metabolic process | positive regulation of protein modification process | response to organic substance | tissue morphogenesis | glycerophospholipid biosynthetic process | 1-phosphatidylinositol-3-kinase activity | branching morphogenesis of an epithelial tube | regulation of kinase activity | regulation of animal organ morphogenesis | positive regulation of steroid biosynthetic process | regulation of intracellular signal transduction | anatomical structure development | developmental growth involved in morphogenesis | branch elongation of an epithelium | cell surface receptor signaling pathway | growth factor activity | metabolic process | regulation of RNA biosynthetic process | Ras guanyl-nucleotide exchange factor activity | receptor ligand activity | protein kinase activity | organic substance metabolic process | nephron morphogenesis | animal organ development | positive regulation of kinase activity | response to heat | regulation of phosphate metabolic process | phosphatidylinositol biosynthetic process | positive regulation of cholesterol metabolic process | positive regulation of endothelial cell migration | positive regulation of MAPK cascade | lung development | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of animal organ formation | ureteric bud elongation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | phosphatidylinositol phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | positive regulation of MAP kinase activity | regulation of developmental process | glycerophospholipid metabolic process | kinase activity | developmental process | cellular protein modification process | tube development | positive regulation of transcription, DNA-templated | response to fibroblast growth factor | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | organ induction | positive regulation of lipid metabolic process | cellular metabolic process | cellular response to organic substance | positive regulation of cell motility | developmental induction | circulatory system development | positive regulation of angiogenesis | nephron tubule development | positive regulation of signaling | signal transduction | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | extracellular matrix | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | cytoplasmic region | extracellular region | cell cortex | membrane-bounded organelle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | cytosol | intracellular
