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QuickView for FIS1 (gene)


Gene Symbol:
FIS1 Homo sapiens Homo sapiens
Full name:
fission, mitochondrial 1
Synonyms:
CGI-135, TTC11, mitochondrial fission 1 protein, FIS1 homolog, H_NH0132A01.6, TPR repeat protein 11, fission 1 (mitochondrial outer membrane) homolog, hFis1, mitochondrial fission molecule, tetratricopeptide repeat domain 11, tetratricopeptide repeat protein 11
Genomic Location:
Chr 7: 100669613-100675091
Description:
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Canis lupus familiaris Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7q22.1


Transcripts Names
NM_016068
Protein Names
Q9Y3D6
Q9BTP3



GO Molecular Function

protein-containing complex binding | signaling receptor binding | protein binding

GO Biological Process

response to extracellular stimulus | protein homooligomerization | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | response to nutrient levels | peroxisome organization | release of cytochrome c from mitochondria | cellular response to glucose stimulus | positive regulation of cellular component organization | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | protein localization to mitochondrion | regulation of localization | organelle fusion | peroxisome fission | regulation of programmed cell death | regulation of mitochondrial fission | establishment of localization | membrane fusion | positive regulation of developmental process | regulation of protein localization to membrane | positive regulation of intrinsic apoptotic signaling pathway | response to hypobaric hypoxia | cellular chemical homeostasis | cell part morphogenesis | glucose homeostasis | cellular response to thapsigargin | regulation of organelle organization | membrane organization | intracellular transport | autophagy of mitochondrion | regulation of neuron death | cellular process | localization | mitochondrial fragmentation involved in apoptotic process | cellular homeostasis | protein transport | mitochondrial fusion | establishment of protein localization to mitochondrion | macromolecule localization | response to hypoxia | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | catabolic process | regulation of cytosolic calcium ion concentration | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular component organization | calcium ion homeostasis | mitochondrion morphogenesis | response to stimulus | regulation of cellular protein localization | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | intracellular protein transport | positive regulation of cellular protein localization | response to peptide | positive regulation of cysteine-type endopeptidase activity | response to glucose | programmed cell death | cellular localization | positive regulation of proteolysis | cellular response to toxic substance | apoptotic mitochondrial changes | cellular response to organic cyclic compound | regulation of protein transport | cellular component assembly | regulation of peptide transport | mitochondrion organization | regulation of intracellular transport | metal ion homeostasis | positive regulation of mitochondrion organization | response to nitrogen compound | apoptotic process | response to oxygen levels | regulation of signal transduction | positive regulation of organelle organization | response to flavonoid | response to activity | cellular glucose homeostasis | regulation of peptidase activity | protein complex oligomerization | regulation of catalytic activity | regulation of intrinsic apoptotic signaling pathway | negative regulation of endoplasmic reticulum calcium ion concentration | organic substance transport | response to lipid | cellular response to peptide | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | cellular ion homeostasis | mitochondrial transport | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | peptide transport | positive regulation of intracellular signal transduction | protein localization to organelle | positive regulation of hydrolase activity | second-messenger-mediated signaling | regulation of cellular protein metabolic process | mitochondrial calcium ion homeostasis | positive regulation of endopeptidase activity | positive regulation of neuron death | response to toxic substance | regulation of apoptotic signaling pathway | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | autophagy | regulation of mitochondrion organization | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | response to monosaccharide | positive regulation of establishment of protein localization | positive regulation of transport | apoptotic signaling pathway | organelle disassembly | positive regulation of molecular function | calcium-mediated signaling | protein-containing complex assembly | regulation of establishment of protein localization | response to organic substance | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | establishment of protein localization to organelle | anatomical structure development | metabolic process | regulation of protein targeting | cellular protein localization | cellular response to carbohydrate stimulus | amide transport | chemical homeostasis | positive regulation of cell death | cell death | positive regulation of programmed cell death | ion homeostasis | establishment of protein localization | positive regulation of intracellular transport | positive regulation of protein transport | regulation of cell communication | signaling | response to organic cyclic compound | positive regulation of mitochondrial fission | protein localization | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule localization | regulation of developmental process | protein targeting to mitochondrion | endoplasmic reticulum calcium ion homeostasis | developmental process | organelle organization | positive regulation of protein targeting to membrane | calcium-mediated signaling using intracellular calcium source | regulation of transport | response to organonitrogen compound | cellular metal ion homeostasis | positive regulation of metabolic process | protein targeting | mitochondrial fission | response to fluoride | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to carbohydrate | positive regulation of mitochondrial calcium ion concentration | carbohydrate homeostasis | divalent inorganic cation homeostasis | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | response to muscle activity

GO Cellular Component

integral component of organelle membrane | peroxisomal membrane | integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | peroxisome | cell | organelle outer membrane | integral component of peroxisomal membrane | intrinsic component of membrane | cytoplasm | intrinsic component of peroxisomal membrane | intracellular organelle | endoplasmic reticulum | protein-containing complex | endomembrane system | mitochondrion | intrinsic component of mitochondrial outer membrane | membrane-bounded organelle | organelle | mitochondrial outer membrane | mitochondrial envelope | outer membrane | integral component of mitochondrial membrane | mitochondrial membrane | intracellular | integral component of mitochondrial outer membrane | membrane