QuickView for FKBP12 (gene)
- Gene Symbol:
- Fkbp1a
Mus musculus - Full name:
- FK506 binding protein 1a
- Synonyms:
- FKBP12, Fkbp, Fkbp1, peptidyl-prolyl cis-trans isomerase FKBP1A, FK506 binding protein 12, PPIase FKBP1A, calstabin-1, immunophilin FKBP12
- Genomic Location:
- Chr 2: 151368235-151387427
- Description:
-
This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor R...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-135 , Predicted Gene Targets for miR-142-3p , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-218 , Predicted Gene Targets for miR-320 , Predicted Gene Targets for miR-338 , Predicted Gene Targets for miR-369-3p , Predicted Gene Targets for miR-381 , Predicted Gene Targets for miR-374
GO Molecular Function
FK506 binding | isomerase activity | enzyme binding | protein-containing complex binding | transforming growth factor beta receptor binding | signaling receptor binding | cytokine receptor binding | catalytic activity | ion channel binding | Hsp70 protein binding | activin binding | identical protein binding | peptidyl-prolyl cis-trans isomerase activity | organic cyclic compound binding | type I transforming growth factor beta receptor binding | protein binding | protein homodimerization activity | protein dimerization activity | drug binding | heat shock protein binding | SMAD binding | heterocyclic compound binding | macrolide binding
GO Biological Process
regulation of activin receptor signaling pathway | negative regulation of phosphorylation | ventricular cardiac muscle tissue morphogenesis | regulation of dephosphorylation | response to cytokine | regulation of cellular localization | muscle tissue development | calcium ion transmembrane import into cytosol | cytosolic calcium ion transport | regulation of localization | heart trabecula morphogenesis | peptidyl-amino acid modification | establishment of localization | regulation of immune system process | negative regulation of cellular process | regulation of phosphatase activity | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | cellular process | localization | cellular homeostasis | chaperone-mediated protein folding | regulation of calcium-mediated signaling | heart morphogenesis | metal ion transport | peptidyl-proline modification | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | regulation of binding | muscle structure development | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | regulation of cytosolic calcium ion concentration | trabecula morphogenesis | positive regulation of cellular protein metabolic process | negative regulation of phosphatase activity | cellular component organization | calcium ion homeostasis | positive regulation of protein binding | T cell activation | calcium ion transport into cytosol | muscle contraction | muscle organ morphogenesis | response to stimulus | positive regulation of protein metabolic process | mononuclear cell proliferation | heart trabecula formation | regulation of protein ubiquitination | cardiac muscle tissue development | muscle tissue morphogenesis | supramolecular fiber organization | cellular localization | divalent metal ion transport | cardiac ventricle morphogenesis | negative regulation of metabolic process | cellular component assembly | protein modification process | macromolecule modification | metal ion homeostasis | response to nitrogen compound | regulation of calcium ion transport into cytosol | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | calcium ion transmembrane transport | response to purine-containing compound | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | amyloid fibril formation | positive regulation of cellular metabolic process | cellular ion homeostasis | animal organ morphogenesis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | regulation of release of sequestered calcium ion into cytosol | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | peptidyl-prolyl cis-trans isomerase activity | cellular protein-containing complex assembly | regulation of calcium ion transmembrane transport | response to xenobiotic stimulus | regulation of amyloid precursor protein catabolic process | cation homeostasis | negative regulation of protein dephosphorylation | striated muscle tissue development | cellular cation homeostasis | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein metabolic process | heart development | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | lymphocyte activation | positive regulation of molecular function | release of sequestered calcium ion into cytosol | regulation of ryanodine-sensitive calcium-release channel activity | cation transmembrane transport | protein-containing complex assembly | protein metabolic process | cardiac ventricle development | positive regulation of protein modification process | response to organic substance | SMAD protein complex assembly | tissue morphogenesis | regulation of protein dephosphorylation | regulation of intracellular signal transduction | ventricular cardiac muscle tissue development | anatomical structure development | cell surface receptor signaling pathway | metabolic process | chemical homeostasis | calcium ion transport | response to caffeine | organic substance metabolic process | regulation of sequestering of calcium ion | protein folding | animal organ development | negative regulation of cellular protein metabolic process | T cell proliferation | ion homeostasis | regulation of phosphate metabolic process | inorganic cation transmembrane transport | response to alkaloid | regulation of ion transmembrane transport | positive regulation of binding | cell activation | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | lymphocyte proliferation | regulation of cell communication | negative regulation of molecular function | transmembrane transport | signaling | regulation of protein binding | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | cellular protein metabolic process | negative regulation of phosphoprotein phosphatase activity | anatomical structure morphogenesis | cation transport | regulation of ion transport | regulation of phosphoprotein phosphatase activity | developmental process | regulation of calcium ion transport | cellular protein modification process | regulation of transport | regulation of cation channel activity | response to organonitrogen compound | cellular metal ion homeostasis | negative regulation of dephosphorylation | cardiac chamber development | negative regulation of hydrolase activity | positive regulation of metabolic process | regulation of calcium ion transmembrane transporter activity | ion transport | protein peptidyl-prolyl isomerization | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | circulatory system development | divalent inorganic cation homeostasis | positive regulation of protein ubiquitination | muscle organ development | muscle system process | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | sarcoplasmic reticulum | intracellular membrane-bounded organelle | synapse | neuron projection | organelle membrane | sarcomere | cell | distal axon | myofibril | cytoplasm | intracellular organelle | endoplasmic reticulum | contractile fiber | presynapse | nuclear outer membrane-endoplasmic reticulum membrane network | cell projection | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | sarcoplasmic reticulum membrane | organelle | I band | axon terminus | sarcoplasm | axon | neuron projection terminus | Z disc | cytosol | intracellular | membrane | supramolecular complex
