QuickView for FLI1;jsessionid=FAC6F26501ACC752D755F6B36741828C (gene)

Gene Symbol:

FLI1 Homo sapiens

Full name:

Fli-1 proto-oncogene, ETS transcription factor

Synonyms:

BDPLT21, EWSR2, SIC-1, Friend leukemia integration 1 transcription factor, Ewing sarcoma breakpoint region 2, Friend leukemia virus integration 1, transcription factor ERGB

Genomic Location:

Chr 11: 128069199-128187521

Description:

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving...

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This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  STAT4_01 ,  TGANTCA_AP1_C ,  DR3_Q4 ,  MZF1_01 ,  HFH3_01 ,  VDR_Q3 ,  HOXA4_Q2 ,  GATA3_01 ,  AP3_Q6 ,  AML_Q6 ,  GATA_Q6 ,  ZF5_01 ,  CATTGTYY_SOX9_B1 ,  STAT6_02 ,  PEA3_Q6 ,  CIZ_01 ,  IPF1_Q4 ,  AACTGGA_MIR145 ,  LYF1_01 ,  E2F_Q6_01 ,  WGTTNNNNNAAA_UNKNOWN ,  FXR_IR1_Q6 ,  GATAAGR_GATA_C ,  IRF1_Q6 ,  MYB_Q5_01 ,  GATA1_04 ,  MYAATNNNNNNNGGC_UNKNOWN ,  AML1_01 ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  TFIII_Q6 ,  CEBPDELTA_Q6 ,  PAX5_02 ,  YYCATTCAWW_UNKNOWN ,  LFA1_Q6 ,  E2F1_Q6_01 ,  CEBP_01 ,  RREB1_01 ,  ETS2_B ,  AP1FJ_Q2 ,  ACCAAAG_MIR9 ,  TAGAACC_MIR182 ,  AP1_Q2_01 ,  NKX61_01 ,  IRF_Q6 ,  PAX6_01 ,  AP2_Q3 ,  HFH8_01 ,  GATA1_02 ,  RACCACAR_AML_Q6 ,  YCATTAA_UNKNOWN ,  RORA1_01 ,  MYB_Q6 ,  AML1_Q6 ,  TTGTTT_FOXO4_01 ,  AFP1_Q6 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  STAT5A_04 ,  ARGGGTTAA_UNKNOWN ,  GATA1_05 ,  IRF7_01 ,  CP2_02 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  E2F1_Q3 ,  AP1_Q2 ,  TBP_01 ,  AACTTT_UNKNOWN ,  E2F_Q3 ,  HNF1_Q6 ,  COREBINDINGFACTOR_Q6 ,  NFKB_C ,  CEBPGAMMA_Q6 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6 ,  TCF11MAFG_01 ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

11q24.3

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