QuickView for FMO1 (gene)

Gene Symbol:

FMO1 Homo sapiens

Full name:

flavin containing monooxygenase 1

Synonyms:

dimethylaniline monooxygenase [N-oxide-forming] 1, FMO 1, Flavin-containing monooxygenase 1 (fetal liver), dimethylaniline oxidase 1, fetal hepatic flavin-containing monooxygenase 1

Genomic Location:

Chr 1: 169484287-169521737

Description:

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, ...

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Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  GATA3_01 ,  GATA_Q6 ,  GATAAGR_GATA_C ,  GATA1_04 ,  GATA6_01 ,  GATA1_02

Cytogenetic Map:

1q24.3

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