QuickView for FNTA (gene)

Gene Symbol:

FNTA Homo sapiens

Full name:

farnesyltransferase, CAAX box, alpha

Synonyms:

FPTA, PGGT1A, PTAR2, protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, FTase-alpha, GGTase-I-alpha, farnesyl-protein transferase alpha-subunit, protein prenyltransferase alpha subunit repeat containing 2, ras proteins prenyltransferase subunit alpha, type I protein geranyl-geranyltransferase alpha subunit

Genomic Location:

Chr 8: 43030599-43060088

Description:

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of t...

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Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGTAG_MIR520D ,  SP1_Q4_01 ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  SP1_Q6 ,  CETS1P54_01 ,  ELK1_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-409-5p

Cytogenetic Map:

8p11.21

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