QuickView for FOLR1;jsessionid=0A90E321004BAB6780431D62A248CD4A (gene)

Gene Symbol:

FOLR1 Homo sapiens

Full name:

folate receptor 1

Synonyms:

FBP, FOLR, folate receptor alpha, FR-alpha, KB cells FBP, adult folate-binding protein, folate binding protein, folate receptor 1 (adult), folate receptor, adult, ovarian tumor-associated antigen MOv18

Genomic Location:

Chr 11: 71578250-71585014

Description:

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Muta...

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The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ZIC3_01 ,  PAX4_02 ,  TEF1_Q6 ,  TAATTA_CHX10_01 ,  IK2_01 ,  GGGTGGRR_PAX4_03

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-299

Cytogenetic Map:

11q13.4

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