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QuickView for FOXC2;jsessionid=7D1D703D6C2B949600F429147F686899 (gene)


Gene Symbol:
FOXC2 Homo sapiens Homo sapiens
Full name:
forkhead box C2
Synonyms:
FKHL14, LD, MFH-1, MFH1, forkhead box protein C2, MFH-1,mesenchyme forkhead 1, forkhead box C2 (MFH-1, mesenchyme forkhead 1), forkhead, Drosophila, homolog-like 14, forkhead-related protein FKHL14, mesenchyme fork head protein 1, mesenchyme forkhead 1, transcription factor FKH-14
Genomic Location:
Chr 16: 85158443-85159948
Description:
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 16
16q24.1


Transcripts Names
NM_005251
Protein Names
Q14DA6
C6KMR9
Q99958



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | DNA binding | promoter-specific chromatin binding | identical protein binding | organic cyclic compound binding | protein binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | chromatin DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | Notch signaling pathway | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | extracellular structure organization | cranial skeletal system development | muscle tissue development | regulation of localization | morphogenesis of an epithelium | regulation of programmed cell death | embryonic viscerocranium morphogenesis | eye development | paraxial mesoderm morphogenesis | response to hormone | mesangial cell development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | glomerular mesangial cell development | cell differentiation | glomerulus development | organ growth | regulation of sprouting angiogenesis | negative regulation of apoptotic process involved in morphogenesis | positive regulation of cell adhesion | positive regulation of cellular component movement | mesenchyme development | blood vessel morphogenesis | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | epithelial tube morphogenesis | mesoderm morphogenesis | tissue remodeling | heart morphogenesis | developmental growth | mesoderm development | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | lymphangiogenesis | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | muscle structure development | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cell adhesion mediated by integrin | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | urogenital system development | positive regulation of epithelial cell migration | lymph vessel morphogenesis | muscle organ morphogenesis | branching involved in blood vessel morphogenesis | regulation of vasculature development | response to stimulus | vasculature development | mesenchymal cell development | pericyte cell differentiation | paraxial mesoderm development | blood vessel remodeling | regulation of blood vessel size | mesoderm formation | cellular nitrogen compound biosynthetic process | cardiac muscle cell proliferation | tube morphogenesis | response to peptide | cardiac muscle tissue development | muscle tissue morphogenesis | epithelial cell development | supramolecular fiber organization | embryonic skeletal system development | cardiovascular system development | cardiac ventricle morphogenesis | positive regulation of sprouting angiogenesis | cellular nitrogen compound metabolic process | extracellular matrix organization | positive regulation of blood vessel endothelial cell migration | blood circulation | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of apoptotic process involved in outflow tract morphogenesis | regulation of wound healing | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | heart growth | negative regulation of apoptotic process involved in development | blood vessel development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | system development | positive regulation of response to wounding | nitrogen compound metabolic process | endothelium development | ureteric bud development | multicellular organism development | glomerulus vasculature development | cellular response to peptide hormone stimulus | cellular response to insulin stimulus | negative regulation of cold-induced thermogenesis | lymph vessel development | paraxial mesodermal cell fate commitment | artery development | regulation of gene expression | kidney epithelium development | cellular response to peptide | insulin receptor signaling pathway | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of cell migration involved in sprouting angiogenesis | regulation of endothelial cell migration | stem cell differentiation | positive regulation of cell migration | cell proliferation | biosynthetic process | aromatic compound biosynthetic process | cell differentiation involved in kidney development | angiogenesis | mesenchyme morphogenesis | regulation of cell adhesion mediated by integrin | mesonephric epithelium development | negative regulation of apoptotic process involved in outflow tract morphogenesis | mesonephros development | sensory organ development | mesodermal cell fate commitment | chordate embryonic development | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | skeletal system morphogenesis | metanephros development | heart development | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | regulation of tube size | embryonic morphogenesis | paraxial mesodermal cell differentiation | nephron development | cardiac muscle tissue growth | glomerular visceral epithelial cell differentiation | embryonic organ morphogenesis | embryonic cranial skeleton morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regionalization | cardiac ventricle development | regulation of growth | response to organic substance | tissue morphogenesis | artery morphogenesis | branching morphogenesis of an epithelial tube | glomerular endothelium development | regulation of animal organ morphogenesis | ventricular cardiac muscle tissue development | response to insulin | embryonic heart tube development | anatomical structure development | cell surface receptor signaling pathway | embryonic skeletal system morphogenesis | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of heart morphogenesis | positive regulation of wound healing | transcription, DNA-templated | positive regulation of endothelial cell migration | stem cell development | morphogenesis of a branching epithelium | camera-type eye development | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of response to wounding | paraxial mesoderm formation | regulation of blood vessel endothelial cell migration | muscle cell proliferation | signaling | somite development | regulation of transcription, DNA-templated | cell development | positive regulation of cell migration involved in sprouting angiogenesis | regulation of developmental growth | collagen fibril organization | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | regulation of organ growth | regulation of developmental process | segmentation | developmental process | vascular endothelial growth factor receptor signaling pathway | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | neural crest cell differentiation | epithelial cell differentiation | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | regulation of vascular wound healing | cardiac chamber development | heterocycle metabolic process | regulation of apoptotic process involved in development | somitogenesis | mesodermal cell differentiation | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of vascular wound healing | positive regulation of metabolic process | ossification | skeletal system development | gastrulation | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | glomerular epithelium development | neural crest cell development | positive regulation of angiogenesis | muscle organ development | signal transduction | mesonephric tubule development | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nuclear body | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular