QuickView for FRA3B (gene)

Gene Symbol:

FHIT Homo sapiens

Full name:

fragile histidine triad

Synonyms:

AP3Aase, FRA3B, bis(5'-adenosyl)-triphosphatase, AP3A hydrolase, diadenosine 5',5'''-P1,P3-triphosphate hydrolase, dinucleosidetriphosphatase

Genomic Location:

Chr 3: 59710076-61212164

Description:

The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all...

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The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Canis lupus familiaris ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGAMTNNNNNTCCY_UNKNOWN ,  NFE2_01 ,  CEBPB_01 ,  CAGGTA_AREB6_01 ,  GGGCGGR_SP1_Q6 ,  ACTWSNACTNY_UNKNOWN ,  AP2REP_01 ,  RTTTNNNYTGGM_UNKNOWN

Cytogenetic Map:

3p14.2

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