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QuickView for FVIII (gene)


Gene Symbol:
F8 Homo sapiens Homo sapiens
Full name:
coagulation factor VIII
Synonyms:
AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, antihemophilic factor, coagulation factor VIII A1 domain, coagulation factor VIII C2 domain, coagulation factor VIII, procoagulant component, coagulation factor VIIIc, factor VIII F8B
Genomic Location:
Chr X: 153717260-153904192
Description:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprote...
Orthologs:
Mus musculus Rattus norvegicus Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Cytogenetic Map:
chr X
Xq28


Transcripts Names
NM_000132
NM_019863
Protein Names
Q5HY69
P00451
Q14286



GO Molecular Function

cation binding | catalytic activity | ion binding | copper ion binding | protein binding | transition metal ion binding | metal ion binding | oxidoreductase activity

GO Biological Process

exocytosis | establishment of localization | platelet degranulation | defense response | membrane organization | intracellular transport | cellular process | secretion | establishment of organelle localization | localization | hemostasis | establishment of localization in cell | vesicle targeting, to, from or within Golgi | organelle localization | cellular component organization | response to stimulus | blood coagulation, intrinsic pathway | COPII-coated vesicle budding | response to stress | cellular localization | secretion by cell | cellular component assembly | vesicle targeting | blood coagulation | nitrogen compound metabolic process | wound healing | blood coagulation, fibrin clot formation | platelet activation | vesicle coating | vesicle-mediated transport | Golgi vesicle budding | acute-phase response | establishment of vesicle localization | regulated exocytosis | protein activation cascade | inflammatory response | Golgi vesicle transport | coagulation | protein-containing complex assembly | protein metabolic process | response to wounding | metabolic process | regulation of body fluid levels | oxidation-reduction process | organic substance metabolic process | vesicle organization | vesicle budding from membrane | cell activation | ER to Golgi vesicle-mediated transport | organelle organization | COPII vesicle coating | vesicle localization | acute inflammatory response | oxidoreductase activity | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | endoplasmic reticulum-Golgi intermediate compartment | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | COPII-coated ER to Golgi transport vesicle | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | platelet alpha granule | Golgi apparatus | endoplasmic reticulum-Golgi intermediate compartment membrane | secretory vesicle | endomembrane system | plasma membrane | Golgi-associated vesicle | vesicle | endoplasmic reticulum lumen | Golgi membrane | extracellular region | membrane-bounded organelle | organelle | extracellular space | cell periphery | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | membrane | platelet alpha granule lumen | vesicle lumen | coated vesicle