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QuickView for FVIII (gene)

Gene Symbol:
F8 Homo sapiens Homo sapiens
Full name:
coagulation factor VIII
AHF, DXS1253E, F8B, F8C, FVIII, HEMA, coagulation factor VIII, antihemophilic factor, coagulation factor VIII A1 domain, coagulation factor VIII C2 domain, coagulation factor VIII, procoagulant component, coagulation factor VIIIc, factor VIII F8B
Genomic Location:
Chr X: 153717260-153904192
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprote...
Mus musculus Rattus norvegicus Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Cytogenetic Map:
chr X

Transcripts Names
Protein Names

GO Molecular Function

cation binding | catalytic activity | ion binding | copper ion binding | protein binding | transition metal ion binding | metal ion binding | oxidoreductase activity

GO Biological Process

exocytosis | establishment of localization | platelet degranulation | defense response | membrane organization | intracellular transport | cellular process | secretion | establishment of organelle localization | localization | hemostasis | establishment of localization in cell | vesicle targeting, to, from or within Golgi | organelle localization | cellular component organization | response to stimulus | blood coagulation, intrinsic pathway | COPII-coated vesicle budding | response to stress | cellular localization | secretion by cell | cellular component assembly | vesicle targeting | blood coagulation | nitrogen compound metabolic process | wound healing | blood coagulation, fibrin clot formation | platelet activation | vesicle coating | vesicle-mediated transport | Golgi vesicle budding | acute-phase response | establishment of vesicle localization | regulated exocytosis | protein activation cascade | inflammatory response | Golgi vesicle transport | coagulation | protein-containing complex assembly | protein metabolic process | response to wounding | metabolic process | regulation of body fluid levels | oxidation-reduction process | organic substance metabolic process | vesicle organization | vesicle budding from membrane | cell activation | ER to Golgi vesicle-mediated transport | organelle organization | COPII vesicle coating | vesicle localization | acute inflammatory response | oxidoreductase activity | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | endoplasmic reticulum-Golgi intermediate compartment | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | COPII-coated ER to Golgi transport vesicle | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | platelet alpha granule | Golgi apparatus | endoplasmic reticulum-Golgi intermediate compartment membrane | secretory vesicle | endomembrane system | plasma membrane | Golgi-associated vesicle | vesicle | endoplasmic reticulum lumen | Golgi membrane | extracellular region | membrane-bounded organelle | organelle | extracellular space | cell periphery | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | membrane | platelet alpha granule lumen | vesicle lumen | coated vesicle