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QuickView for FYN;jsessionid=F04BA1B985B952B967339AE009D51915 (gene)


Gene Symbol:
FYN Homo sapiens Homo sapiens
Full name:
FYN proto-oncogene, Src family tyrosine kinase
Synonyms:
SLK, SYN, p59-FYN, tyrosine-protein kinase Fyn, FYN oncogene related to SRC, FGR, YES, OKT3-induced calcium influx regulator, c-syn protooncogene, proto-oncogene Syn, proto-oncogene c-Fyn, src-like kinase, src/yes-related novel, tyrosine kinase p59fyn(T)
Genomic Location:
Chr 6: 112089178-112301320
Description:
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding dis...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6q21





GO Molecular Function

phosphatidylinositol 3-kinase binding | ephrin receptor binding | guanyl-nucleotide exchange factor activity | CD8 receptor binding | GTPase binding | cation binding | alpha-tubulin binding | hormone receptor binding | G-protein coupled glutamate receptor binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | disordered domain specific binding | nucleotide binding | CD4 receptor binding | signaling receptor binding | carbohydrate derivative binding | type 5 metabotropic glutamate receptor binding | Ras GTPase binding | molecular function regulator | catalytic activity | ion channel binding | protein domain specific binding | ATP binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | tau protein binding | purine nucleotide binding | phosphatidylinositol 3-kinase activity | identical protein binding | ion binding | organic cyclic compound binding | peptide hormone receptor binding | purine ribonucleoside triphosphate binding | T cell receptor binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | growth factor receptor binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | glutamate receptor binding | small molecule binding

GO Biological Process

positive regulation of immune response | response to extracellular stimulus | brain development | adaptive immune response | cell morphogenesis | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | heart process | response to nutrient levels | guanyl-nucleotide exchange factor activity | detection of stimulus | response to cytokine | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | immune response-regulating signaling pathway | regulation of cellular localization | intracellular signal transduction | cellular response to platelet-derived growth factor stimulus | regulation of cell development | regulation of localization | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | phosphatidylinositol metabolic process | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | regulation of cell shape | negative regulation of neuron death | neuron migration | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | regulation of protein localization to membrane | cell differentiation | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | detection of mechanical stimulus involved in sensory perception | nervous system development | cellular response to extracellular stimulus | response to drug | lymphocyte costimulation | response to glycine | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | generation of neurons | response to antibiotic | sensory perception of mechanical stimulus | innate immune response activating cell surface receptor signaling pathway | phospholipid metabolic process | regulation of neuron death | innate immune response-activating signal transduction | cellular process | Fc-gamma receptor signaling pathway involved in phagocytosis | localization | cell projection morphogenesis | positive regulation of non-membrane spanning protein tyrosine kinase activity | negative regulation of signaling | metal ion transport | negative regulation of synapse organization | neuron development | dendritic spine organization | learning | positive regulation of protein kinase activity | hemostasis | negative regulation of apoptotic process | axon guidance | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of apoptotic signaling pathway | activated T cell proliferation | response to hydrogen peroxide | regulation of protein kinase B signaling | peptidyl-tyrosine autophosphorylation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | negative regulation of oxidative stress-induced cell death | cellular response to organonitrogen compound | ephrin receptor signaling pathway | cellular component organization | cellular lipid metabolic process | MAPK cascade | response to transforming growth factor beta | T cell activation | head development | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | positive regulation of innate immune response | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | mononuclear cell proliferation | positive regulation of phosphatidylinositol 3-kinase signaling | response to singlet oxygen | response to stress | neuron projection guidance | positive regulation of JAK-STAT cascade | positive regulation of cellular protein localization | regulation of protein ubiquitination | response to peptide | positive regulation of cell-cell adhesion | positive regulation of cysteine-type endopeptidase activity | response to L-glutamate | positive regulation of cell activation | activation of innate immune response | divalent metal ion transport | response to alcohol | positive regulation of proteolysis | positive regulation of T cell activation | immune response-activating signal transduction | regulation of protein transport | negative regulation of metabolic process | protein modification process | regulation of synapse structure or activity | regulation of peptide transport | regulation of cell adhesion | negative regulation of reactive oxygen species biosynthetic process | macromolecule modification | regulation of intracellular transport | molecular function regulator | response to ethanol | leukocyte migration | blood coagulation | negative regulation of dendritic spine maintenance | regulation of cellular response to stress | detection of abiotic stimulus | locomotion | response to nitrogen compound | negative regulation of neuron apoptotic process | regulation of calcium ion transport into cytosol | cellular response to hormone stimulus | regulation of protein tyrosine kinase activity | system development | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of neuron projection development | multicellular organism development | cell migration | cellular response to peptide hormone stimulus | regulation of peptidase activity | phosphorus metabolic process | response to amino acid | learning or memory | positive regulation of protein kinase B signaling | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | wound healing | Fc-gamma receptor signaling pathway | regulation of T cell activation | detection of mechanical stimulus involved in sensory perception of pain | regulation of neuron differentiation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | platelet activation | negative regulation of hydrogen peroxide biosynthetic process | axon development | nervous system process | cellular response to peptide | positive regulation of intracellular protein transport | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of protein localization to nucleus | regulation of synapse organization | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of cell projection organization | positive regulation of STAT cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | response to nutrient | phosphatidylinositol 3-kinase activity | response to oxidative stress | synapse organization | axonogenesis | positive regulation of hydrolase activity | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | cognition | response to platelet-derived growth factor | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | positive regulation of protein localization to nucleus | sensory perception of pain | regulation of cellular protein metabolic process | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | positive regulation of endopeptidase activity | regulation of calcium ion transmembrane transport | positive regulation of neuron death | response to toxic substance | regulation of hydrogen peroxide metabolic process | regulation of apoptotic signaling pathway | cellular response to amino acid stimulus | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | cellular response to drug | lipid phosphorylation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | positive regulation of tyrosine phosphorylation of STAT protein | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of protein metabolic process | positive regulation of signal transduction | lipid modification | positive regulation of establishment of protein localization | regulation of protein phosphorylation | glycerolipid metabolic process | cellular response to glycine | negative regulation of protein ubiquitination | positive regulation of transport | viral process | coagulation | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | lymphocyte activation | protein tyrosine kinase activity | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | neuron differentiation | activation of immune response | protein metabolic process | cellular response to nutrient | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | negative regulation of cell projection organization | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | response to mechanical stimulus | import into cell | detection of stimulus involved in sensory perception | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cellular component maintenance | cell projection organization | metabolic process | positive regulation of cell development | negative regulation of response to oxidative stress | regulation of defense response to virus by virus | regulation of protein catabolic process | regulation of protein targeting | positive regulation of leukocyte activation | regulation of body fluid levels | negative regulation of programmed cell death | negative regulation of hydrogen peroxide metabolic process | regulation of calcium ion import across plasma membrane | Ras guanyl-nucleotide exchange factor activity | calcium ion transport | endocytosis | behavior | positive regulation of cell death | immune response | protein kinase activity | neuron projection development | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | forebrain development | negative regulation of cellular protein metabolic process | T cell proliferation | regulation of cell activation | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of dendritic spine maintenance | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | detection of mechanical stimulus | positive regulation of intracellular transport | regulation of postsynapse organization | cell activation | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | dendrite morphogenesis | negative regulation of protein catabolic process | negative regulation of protein metabolic process | sensory perception | regulation of calcium ion import | T cell costimulation | lymphocyte proliferation | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | feeding behavior | response to amyloid-beta | cell development | dendritic spine maintenance | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | cellular protein metabolic process | phosphatidylinositol phosphorylation | anatomical structure morphogenesis | regulation of endopeptidase activity | cation transport | dendrite development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | glycerophospholipid metabolic process | kinase activity | developmental process | Fc receptor signaling pathway | regulation of calcium ion transport | cellular protein modification process | positive regulation of protein targeting to membrane | vascular endothelial growth factor receptor signaling pathway | Fc receptor mediated stimulatory signaling pathway | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | response to organonitrogen compound | stimulatory C-type lectin receptor signaling pathway | regulation of glutamate receptor signaling pathway | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | positive regulation of neuron differentiation | ion transport | regulation of cell projection organization | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | chemotaxis | phagocytosis | positive regulation of leukocyte cell-cell adhesion | cellular response to L-glutamate | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | cytoplasmic side of plasma membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | extrinsic component of membrane | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | cytoplasmic side of membrane | extrinsic component of plasma membrane | cytoplasm | intracellular organelle | actin cytoskeleton | endoplasmic reticulum | membrane microdomain | dendritic tree | glial cell projection | cell projection | endomembrane system | postsynapse | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | membrane raft | vesicle | perinuclear region of cytoplasm | postsynaptic density | asymmetric synapse | mitochondrion | endosome | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | cell periphery | perinuclear endoplasmic reticulum | cytosol | intracellular vesicle | actin filament | cytoskeleton | intracellular | membrane | supramolecular complex