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Name: Famotidine
PubChem Compound ID: 3325
Description: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Molecular formula: C8H15N7O2S3
Molecular weight: 337.449 g/mol
Famodin; Novo-Famotidine; Famotidine (JP15/USP); Famodil; N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide; Cepal; Ferotine; Ulceprax; Pepzan; Invigan.
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Name: Famotidine
Name (isomeric): DB00927
Drug Type: small molecule
Description: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Famotidinum [Latin]; Famotidina [Spanish]
Brand: Gastrosidin, Famodin, Famodil, Weimok, Tipodex, Famodar, Peptan, Apogastine, Nulceran, Famopsin, Fadin, Sedanium-R, Rubacina, Ulfinol, Nulcerin, Famovane, Amfamox, Whitidin, Pepcid RPD, Ulgarine, Cuantin, Famoxal, Pepdul, Motiax, Dispronil, Ulfam, Evatin, Huberdina, Durater, Dispromil, Lecedil, Purifam, Invigan, Fanox, Cepal, Mensoma, Brolin, Novo-Famotidine, Mosul, Nu-Famotidine, Panalba, Fanosin, Famtac, Ulfagel, Gaster, Antodine, Pepcidin, Pepcidine, Gastrofam, Famosan, Pepcidina, Famotep, Pepfamin, Fadyn, Quamatel, Muclox, Famonit, Pepcid AC, Tairal, Famocid, Topcid, Duovel, Ferotine, Fudone, Fadine, Yamarin, Famos, Famox, Peptidin, Gastrodomina, Hacip, Dinul, Logos, Ulceprax, Fanobel, Famodine, Dipsin, Famulcer, Famo, Ulcofam, Fluxid, Famotin, Sigafam, Famowal, Bestidine, Vagostal, Pepdif, Peptifam, Nevofam, Gastro, Pepcid, Ulfamid, Farmotex, Renapepsa, Famotal, Dibrit 40, Tamin, Ingastri, Cronol, Ganor, Confobos, Neocidine, Pepzan, Blocacid, Gastridin, Gastropen, Midefam, Fagastine, Mylanta AR, Gastridan, H2 Bloc, Pepdine, Quamtel, Apo-Famotidine, Gastrion, Rogasti, Pepcidin Rapitab, Ulcatif, Digervin, Supertidine, Notidin, Famogard, Restadin, Fibonel
Category: Anti-Ulcer Agents, Histamine H2 Antagonists
CAS number: 76824-35-6
Indication: For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an incr...
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Mechanism of Action:
Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including foo...
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Absorption: The bioavailability of oral doses is 40-45%.
Protein binding: 15-20%
Biotransformation: Hepatic.
Route of elimination: Renal clearance is 250-450 mL/min, indicating some tubular excretion.
Half Life: 2.5-3.5 hours
Clearance: renal cl=250-450 mL/min
Toxicity: Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
Affected organisms: Humans and other mammals
Food interaction:
Avoid alcohol.
Take without regard to meals, food may slightly increase the product's bioavailability.
Limit caffeine intake.
Drug interaction:
AtazanavirThis gastric pH modifier decreases the levels/effects of atazanavir
ItraconazoleThe H2-receptor antagonist, famotidine, may decrease the absorption of itraconazole.
EnoxacinFamotidine may decrease the absorption of enoxacin.
CefditorenH2-Antagonists such as famotidine may decrease the serum concentration of cefditoren. Cefditoren prescribing information recommends to avoid concomitant use with H2-antagonists (eg, famotidine, ranitidine) and antacids as well. Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of H2-antagonists can not be avoided.
KetoconazoleThe H2-receptor antagonist, famotidine, may decrease the absorption of ketoconazole.