QuickView for Fgf8 (gene)
- Gene Symbol:
- FGF8
Homo sapiens - Full name:
- fibroblast growth factor 8
- Synonyms:
- AIGF, FGF-8, HBGF-8, HH6, KAL6, fibroblast growth factor 8, androgen-induced growth factor, fibroblast growth factor 8 (androgen-induced), heparin-binding growth factor 8
- Genomic Location:
- Chr 10: 103519877-103525817
- Description:
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGGAAA_NFAT_Q4_01 , E12_Q6 , PBX1_02 , SMTTTTGT_UNKNOWN , STAT4_01 , SRF_Q6 , STAT6_01 , E2A_Q2 , TATAAA_TATA_01 , CDPCR3HD_01
- Cytogenetic Map:
-
10q24.32
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | enzyme binding | signaling receptor binding | Ras GTPase binding | molecular function regulator | catalytic activity | phosphatidylinositol 3-kinase activity | fibroblast growth factor receptor binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein tyrosine kinase activity | protein binding | receptor regulator activity | 1-phosphatidylinositol-3-kinase activity | growth factor activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | receptor ligand activity | protein kinase activity | chemoattractant activity | transferase activity | small GTPase binding | growth factor receptor binding | kinase activity
GO Biological Process
signal transduction involved in regulation of gene expression | regulation of ERK1 and ERK2 cascade | brain development | limb development | cell morphogenesis | inner ear morphogenesis | regulation of cell cycle process | guanyl-nucleotide exchange factor activity | positive regulation of cellular component organization | cell motility | pharyngeal system development | neuron projection morphogenesis | developmental process involved in reproduction | intracellular signal transduction | otic vesicle development | subpallium development | morphogenesis of an epithelium | gonad development | regulation of programmed cell death | peptidyl-amino acid modification | phosphatidylinositol metabolic process | forebrain morphogenesis | branching involved in salivary gland morphogenesis | negative regulation of neuron death | negative regulation of cellular process | neural tube patterning | positive regulation of developmental process | embryonic appendage morphogenesis | bone development | otic vesicle formation | cell differentiation | respiratory tube development | nervous system development | epithelial to mesenchymal transition | response to drug | cell part morphogenesis | neurogenesis | epithelial to mesenchymal transition involved in endocardial cushion formation | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | generation of neurons | phosphatidylinositol-3-phosphate biosynthetic process | mesenchyme development | salivary gland morphogenesis | phospholipid metabolic process | blood vessel morphogenesis | pattern specification process | regulation of neuron death | cellular process | negative regulation of muscle organ development | localization | cell projection morphogenesis | epithelial tube morphogenesis | limb morphogenesis | odontogenesis | tissue remodeling | heart morphogenesis | neuron development | central nervous system neuron differentiation | determination of left/right symmetry | reproductive system development | canonical Wnt signaling pathway | mesoderm development | epithelium migration | regulation of mitotic nuclear division | renal tubule morphogenesis | regulation of striated muscle tissue development | glandular epithelial cell differentiation | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | axon guidance | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | forebrain neuron differentiation | positive regulation of cell division | diencephalon development | tissue development | regulation of cell differentiation | hindlimb morphogenesis | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | pituitary gland development | regulation of odontogenesis of dentin-containing tooth | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | cellular lipid metabolic process | MAPK cascade | regulation of cell division | urogenital system development | rostrocaudal neural tube patterning | nephron tubule morphogenesis | development of primary sexual characteristics | head development | negative regulation of cardiac muscle tissue development | thyroid gland development | branching involved in blood vessel morphogenesis | response to stimulus | vasculature development | cell morphogenesis involved in neuron differentiation | embryonic limb morphogenesis | respiratory system development | cellular response to fibroblast growth factor stimulus | blood vessel remodeling | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | determination of heart left/right asymmetry | gland morphogenesis | response to stress | neuron projection guidance | regulation of cell proliferation | tube morphogenesis | programmed cell death | forebrain regionalization | epithelial tube formation | reproduction | cardiovascular system development | negative regulation of muscle tissue development | brain morphogenesis | protein modification process | regulation of odontogenesis | cellular biosynthetic process | dorsal/ventral pattern formation | kidney development | embryo development | macromolecule modification | adenohypophysis development | cell-cell signaling | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | positive chemotaxis | blood vessel development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | locomotion | negative regulation of neuron apoptotic process | central nervous system neuron development | response to BMP | apoptotic process | endocardial cushion development | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | ureteric bud development | Wnt signaling pathway | multicellular organism development | cell migration | regulation of MAPK cascade | phosphorus metabolic process | neuroepithelial cell differentiation | positive regulation of protein kinase B signaling | lipid metabolic process | forebrain neuron development | regulation of phosphorylation | kidney morphogenesis | fibroblast growth factor receptor signaling pathway | cardiac epithelial to mesenchymal transition | telencephalon development | artery development | positive regulation of cell cycle | determination of bilateral symmetry | positive regulation of mitotic cell cycle | regulation of gene expression | kidney epithelium development | axon development | dorsal/ventral axon guidance | outflow tract morphogenesis | endocardial cushion morphogenesis | organophosphate metabolic process | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | phospholipid biosynthetic process | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | neural plate morphogenesis | phosphatidylinositol 3-kinase activity | response to oxidative stress | axonogenesis | positive regulation of cell differentiation | cell proliferation | biosynthetic process | neural tube development | regulation of cellular protein metabolic process | angiogenesis | mesenchyme morphogenesis | phosphorylation | mesonephric epithelium development | cardiac septum morphogenesis | lipid biosynthetic process | heart looping | forebrain dorsal/ventral pattern formation | endocrine system development | protein phosphorylation | cell morphogenesis involved in differentiation | mesodermal cell migration | mesonephros development | phosphate-containing compound metabolic process | sensory organ development | lipid phosphorylation | chordate embryonic development | cell communication | corticotropin hormone secreting cell differentiation | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of neuron apoptotic process | metanephros development | renal tubule development | mesendoderm development | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | negative regulation of striated muscle tissue development | heart development | lipid modification | positive regulation of cell proliferation | regulation of protein phosphorylation | neuroendocrine cell differentiation | embryo development ending in birth or egg hatching | glycerolipid metabolic process | regulation of RNA metabolic process | renal system development | genitalia development | embryonic hindlimb morphogenesis | embryonic morphogenesis | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | regulation of mitotic cell cycle | nephron development | cell proliferation in forebrain | protein tyrosine kinase activity | neuron differentiation | embryonic organ morphogenesis | regulation of signaling receptor activity | receptor regulator activity | ureteric bud morphogenesis | positive regulation of organ growth | protein metabolic process | regionalization | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | artery morphogenesis | glycerophospholipid biosynthetic process | 1-phosphatidylinositol-3-kinase activity | branching morphogenesis of an epithelial tube | male sex differentiation | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | embryonic heart tube development | anatomical structure development | cell surface receptor signaling pathway | aorta development | growth factor activity | cell migration involved in mesendoderm migration | cell projection organization | metabolic process | cell fate commitment | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of programmed cell death | embryonic organ development | ear development | Ras guanyl-nucleotide exchange factor activity | forebrain generation of neurons | morphogenesis of embryonic epithelium | receptor ligand activity | male genitalia development | protein kinase activity | neuron projection development | organic substance metabolic process | cell death | chemoattractant activity | nephron morphogenesis | animal organ development | forebrain development | pallium development | neural plate development | positive regulation of ERK1 and ERK2 cascade | neural precursor cell proliferation | regulation of phosphate metabolic process | phosphatidylinositol biosynthetic process | dopaminergic neuron differentiation | positive regulation of MAPK cascade | aorta morphogenesis | lung development | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | regulation of animal organ formation | BMP signaling pathway | regulation of cell communication | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of transcription, DNA-templated | thyroid-stimulating hormone-secreting cell differentiation | response to organic cyclic compound | cell development | regulation of developmental growth | positive regulation of phosphorylation | cell migration involved in gastrulation | cellular protein metabolic process | endocardial cushion formation | endoderm development | phosphatidylinositol phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of organ growth | reproductive structure development | regulation of developmental process | glycerophospholipid metabolic process | kinase activity | developmental process | positive regulation of cell cycle process | cardiac septum development | cellular protein modification process | tube development | response to fibroblast growth factor | lung morphogenesis | epithelial cell differentiation | cardiac chamber development | tube formation | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular response to BMP stimulus | organ induction | mesendoderm migration | skeletal system development | gastrulation | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | exocrine system development | regulation of cell death | sex differentiation | salivary gland development | negative regulation of cell death | developmental induction | circulatory system development | chemotaxis | ear morphogenesis | nephron tubule development | motor neuron axon guidance | regulation of cellular component organization | otic vesicle morphogenesis | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | mesonephric tubule development | positive regulation of gene expression | outflow tract septum morphogenesis | cellular response to growth factor stimulus | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | midbrain-hindbrain boundary development | regulation of phosphorus metabolic process
GO Cellular Component
cell | external side of plasma membrane | plasma membrane | extracellular region | cell periphery | cell surface | intracellular | membrane
