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QuickView for Flavoxate (compound)
PubChem
| Name: | Flavoxate |
|---|---|
| PubChem Compound ID: | 19483 |
| Description: | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. |
| Molecular formula: | C24H26ClNO4 |
| Molecular weight: | 427.92 g/mol |
| Synonyms: |
4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-piperidinoethyl ester, hydrochloride; Flavoxate hydrochloride [USAN:JAN]; NSC 114649; 2-Piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate hydrochloride; Genurin; 3717-88-2; Peflate; DW-61; Flavoxate Hydrochloride; NSC-114649.
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DrugBank
Identification
| Name: | Flavoxate |
|---|---|
| Name (isomeric): | DB01148 |
| Drug Type: | small molecule |
| Description: | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. |
| Synonyms: |
Flavoxate HCL; Flavoxate HCI
|
| Brand: | Urispas |
| Category: | Parasympatholytics |
| CAS number: | 15301-69-6 |
Pharmacology
| Indication: | For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis. |
|---|---|
| Pharmacology: |
Flavoxate is a spasmolytic flavone derivative that acts by relaxing the smooth muscle in the urinary tract. Flavoxate is a competitive muscarinic receptor antagonist indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. Muscarinic receptors play an important role in several maj...
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| Mechanism of Action: |
Flavoxate acts as a direct antagonist at muscarinic acetylcholine receptors in cholinergically innervated organs. Its anticholinergic-parasympatholytic action reduces the tonus of smooth muscle in the bladder, effectively reducing the number of required voids, urge incontinence episodes, urge severity and improving retention, facilitating increased...
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| Absorption: | Well absorbed from gastrointestinal tract. |
| Route of elimination: | 57% of the flavoxate HCl was excreted in the urine within 24 hours. |
| Toxicity: | The oral LD50 for flavoxate HCl in rats is 4273 mg/kg. The oral LD50 for flavoxate HCl in mice is 1837 mg/kg. Symptoms of overdose include convulsions, decreased ability to sweat, (warm, red skin, dry mouth, and increased body temperature), hallucinations, increased heart rate and blood pressure, and mental confusion. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
