QuickView for Flt1 (gene)

Gene Symbol:

FLT1 Homo sapiens

Full name:

fms related tyrosine kinase 1

Synonyms:

FLT, FLT-1, VEGFR-1, VEGFR1, vascular endothelial growth factor receptor 1, fms-like tyrosine kinase 1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), tyrosine-protein kinase FRT, tyrosine-protein kinase receptor FLT, vascular permeability factor receptor

Genomic Location:

Chr 13: 27774389-27967265

Description:

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This prote...

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This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT4_01 ,  TTANTCA_UNKNOWN ,  CREBP1CJUN_01 ,  GNCF_01 ,  MZF1_01 ,  RYTTCCTG_ETS2_B ,  AML_Q6 ,  STAT6_02 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  AMEF2_Q6 ,  TTF1_Q6 ,  MAF_Q6 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  TATAAA_TATA_01 ,  GTGACGY_E4F1_Q6 ,  LFA1_Q6 ,  SP3_Q3 ,  CREB_02 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  CCCNNGGGAR_OLF1_01 ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  NKX25_02 ,  STAT_01 ,  GACAGGG_MIR339 ,  RNGTGGGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  TGACGTCA_ATF3_Q6 ,  TTCYNRGAA_STAT5B_01 ,  AAGCACT_MIR520F ,  STAT5A_01 ,  MMEF2_Q6 ,  PAX4_03 ,  ACAGGGT_MIR10A_MIR10B ,  CREB_Q2_01 ,  CREB_01 ,  GGGTGGRR_PAX4_03 ,  TGASTMAGC_NFE2_01 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-93

Cytogenetic Map:

13q12.3

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