QuickView for Flt3 (gene)

Gene Symbol:

FLT3 Homo sapiens

Full name:

fms related tyrosine kinase 3

Synonyms:

CD135, FLK-2, FLK2, STK1, receptor-type tyrosine-protein kinase FLT3, CD135 antigen, FL cytokine receptor, fetal liver kinase 2, fms-like tyrosine kinase 3, growth factor receptor tyrosine kinase type III, stem cell tyrosine kinase 1

Genomic Location:

Chr 13: 27475411-27572729

Description:

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosph...

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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ARNT_01 ,  CACGTG_MYC_Q2 ,  OSF2_Q6 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  MYCMAX_01 ,  USF_C ,  E47_01 ,  NMYC_01 ,  CTGCAGY_UNKNOWN ,  CTCTAGA_MIR526C_MIR518F_MIR526A

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-376c

Cytogenetic Map:

13q12.2

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