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QuickView for Flt4 (gene)


Gene Symbol:
FLT4 Homo sapiens Homo sapiens
Full name:
fms related tyrosine kinase 4
Synonyms:
FLT-4, FLT41, LMPH1A, PCL, VEGFR-3, VEGFR3, vascular endothelial growth factor receptor 3, fms-like tyrosine kinase 4, tyrosine-protein kinase receptor FLT4
Genomic Location:
Chr 5: 179961112-180009206
Description:
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5q35.3





GO Molecular Function

transmembrane receptor protein tyrosine kinase activity | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | growth factor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | vascular endothelial growth factor-activated receptor activity | signaling receptor activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | VEGF-C-activated receptor activity | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein homodimerization activity | protein phosphatase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | respiratory gaseous exchange | positive regulation of locomotion | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | negative regulation of cellular process | cell differentiation | positive regulation of epithelial cell proliferation | respiratory tube development | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | blood vessel morphogenesis | cellular process | regulation of cell motility | negative regulation of signaling | negative regulation of apoptotic process | response to growth factor | positive regulation of nitrogen compound metabolic process | lymphangiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | regulation of blood vessel remodeling | positive regulation of cellular protein metabolic process | positive regulation of epithelial cell migration | sprouting angiogenesis | lymph vessel morphogenesis | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | vasculature development | cellular response to vascular endothelial growth factor stimulus | respiratory system development | positive regulation of protein metabolic process | positive regulation of protein kinase C signaling | regulation of cell proliferation | tube morphogenesis | positive regulation of vascular endothelial growth factor production | cardiovascular system development | protein modification process | macromolecule modification | blood vessel development | regulation of cellular response to stress | lung alveolus development | system development | nitrogen compound metabolic process | regulation of signal transduction | respiratory system process | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | lymph vessel development | regulation of phosphorylation | vascular endothelial growth factor-activated receptor activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | vascular endothelial growth factor signaling pathway | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of JNK cascade | positive regulation of intracellular signal transduction | regulation of cellular component movement | regulation of endothelial cell migration | positive regulation of cell migration | regulation of cellular protein metabolic process | angiogenesis | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase C signaling | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | VEGF-C-activated receptor activity | protein tyrosine kinase activity | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | negative regulation of programmed cell death | regulation of tissue remodeling | protein kinase activity | organic substance metabolic process | animal organ development | regulation of endothelial cell proliferation | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | positive regulation of cytokine production | regulation of JNK cascade | positive regulation of endothelial cell migration | positive regulation of MAPK cascade | lung development | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | regulation of developmental process | kinase activity | developmental process | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | tube development | regulation of vascular endothelial growth factor production | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | nucleoplasm | plasma membrane | integral component of plasma membrane | extracellular region | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | intracellular | membrane | intrinsic component of plasma membrane