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QuickView for Flunisolide (compound)


PubChem
Name: flunisolide
PubChem Compound ID: 11954221
Molecular formula: C48H64F2O13
Molecular weight: 887.011 g/mol
Synonyms:
Nasalide; Flunisolide; 77326-96-6; D00324; Flunisolide (JAN/USP); Nasalide (TN)
DrugBank
Identification
Name: flunisolide
Name (isomeric): DB00180
Drug Type: small molecule
Synonyms:
Flunisolide [anhydrous]
Brand: Nasarel, Lunis, Aerobid, Bronalide, Rhinalar, Nasalide, Synaclyn, Syntaris
Category: Anti-Asthmatic Agents, Anti-inflammatory Agents
CAS number: 3385-03-3
Pharmacology
Indication: For the maintenance treatment of asthma as a prophylactic therapy.
Pharmacology:
Flunisolide is a synthetic corticosteroid. It is administered either as an oral metered-dose inhaler for the treatment of asthma or as a nasal spray for treating allergic rhinitis. Corticosteroids are naturally occurring hormones that prevent or suppress inflammation and immune responses. When given as an intranasal spray, flunisolide reduces water...
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Mechanism of Action:
Flunisolide is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in th...
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Absorption: Absorbed rapidly
Protein binding: Approximately 40% after oral inhalation
Biotransformation: Primarily hepatic, converted to the S beta-OH metabolite.
Half Life: 1.8 hours
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
VoriconazoleVoriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of flunisolide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of flunisolide if voriconazole is initiated, discontinued or dose changed.
TelithromycinTelithromycin may reduce clearance of Flunisolide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Flunisolide if Telithromycin is initiated, discontinued or dose changed.

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