QuickView for Fmi (gene)

Gene Symbol:

PTPRU Homo sapiens

Full name:

protein tyrosine phosphatase, receptor type U

Synonyms:

FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J, receptor-type tyrosine-protein phosphatase U, PTP pi, Receptor protein tyrosine phosphatase hPTP-J, pancreatic carcinoma phosphatase 2, pi R-PTP-Psi, protein-tyrosine phosphatase J, protein-tyrosine phosphatase pi, protein-tyrosine phosphatase receptor omicron, receptor-type protein-tyrosine phosphatase psi

Genomic Location:

Chr 1: 29435634-29525903

Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two ...

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACTGTAG_MIR139 ,  TGANTCA_AP1_C ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  AGCGCTT_MIR518F_MIR518E_MIR518A ,  ATF4_Q2 ,  CREB_Q4 ,  CTTTGTA_MIR524 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  ATF_01 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  ATF3_Q6 ,  GACAATC_MIR219 ,  E2F1_Q3_01 ,  GCGCTTT_MIR518B_MIR518C_MIR518D ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  CEBP_C ,  CREB_Q2 ,  TGACGTCA_ATF3_Q6 ,  CREB_Q2_01 ,  CREB_01 ,  TAXCREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-219

Cytogenetic Map:

1p35.3

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