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QuickView for Folic acid (compound)
PubChem
| Name: | Folic Acid |
|---|---|
| PubChem Compound ID: | 1549092 |
| Description: | A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. |
| Molecular formula: | C19H17N7O6-2 |
| Molecular weight: | 439.382 g/mol |
| Synonyms: |
ZINC01532675
|
DrugBank
Identification
| Name: | Folic Acid |
|---|---|
| Name (isomeric): | DB00158 |
| Drug Type: | small molecule |
| Description: | A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. |
| Synonyms: |
Pteroylglutamic acid; Pteroyl-L-glutamic acid; Pteroyl-L-monoglutamic acid; Pteroylmonoglutamic acid; Vitamin Bc; Vitamin B9; PGA; Vitamin M; Vitamin Be; Folate
|
| Brand: | Folacin, Folcidin, Foliamin, Folvite, Folsan, Folettes, Folacid, Acifolic, Cytofol, Incafolic, Folvron, Folsav, Apo-Folic, Millafol, Foldine, Folicet, Folbal, Folipac, Dosfolat B activ, Folsaure |
| Category: | Micronutrient, Vitamin B Complex, Hematinics, Dietary supplement |
| CAS number: | 59-30-3 |
Pharmacology
| Indication: | For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood. |
|---|---|
| Pharmacology: | Folic acid, a water-soluble B-complex vitamin, is found in foods such as liver, kidneys, yeast, and leafy, green vegetables. Folic acid is used to diagnose folate deficiency and to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid. |
| Mechanism of Action: |
Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino...
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| Protein binding: | Very high to plasma protein |
| Biotransformation: | Hepatic |
| Route of elimination: | Folic Acid is metabolized in the liver to 7, 8-dihydrofolic acid and eventually to 5,6,7,8-tetrahydrofolic acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Folic Acid is also excreted in the milk of lactating mothers. |
| Toxicity: | IPR-MUS LD50 85 mg/kg,IVN-GPG LD50 120 mg/kg, IVN-MUS LD50 239 mg/kg, IVN-RAT LD50 500 mg/kg, IVN-RBT LD50 410 mg/kg |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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