Name: | forasartan |
---|---|
PubChem Compound ID: | 132706 |
Molecular formula: | C23H28N8 |
Molecular weight: | 416.522 g/mol |
Synonyms: |
145216-43-9; Pyridine, 5-((3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl)-2-(2-(1H-tetrazol-5-yl)phenyl)-; Forasartan; SC 52458; 5-((3,5-Dibutyl-1H-1,2,4-triazol-1-yl)methyl)-2-(2-(1H-tetrazol-5-ylphenyl))pyridine
|
Name: | forasartan |
---|---|
Name (isomeric): | DB01342 |
Drug Type: | small molecule |
Category: | Angiotensin II Receptor Antagonists, Antihypertensive Agents |
CAS number: | 145216-43-9 |
Indication: | For the treatment of hypertension. |
---|---|
Pharmacology: |
Forasartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. By inhibiting angiotensin II receptors, this drug leads to a decrease in sodium reabsorption (which decreases water content of blood) and a decrease in vasoconstriction. Combined, this has the effect of lowering blood pressur...
show more » |
Mechanism of Action: |
Forasartan competes with angiotensin II for binding at the AT1 receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance. Also, since angiotensin causes vasoconstriction, the inhibition of this rec...
show more » |
Affected organisms: | Humans and other mammals |
Drug interaction: |
|
---|