QuickView for Forkhead Box Protein O3 (gene)

Gene Symbol:

FOXO3 Homo sapiens

Full name:

forkhead box O3

Synonyms:

AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box protein O3, forkhead box O3A, forkhead homolog (rhabdomyosarcoma) like 1, forkhead in rhabdomyosarcoma-like 1, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

Genomic Location:

Chr 6: 108987719-109112664

Description:

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcrip...

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This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  TGIF_01 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  STAT6_02 ,  E4BP4_01 ,  AACTGAC_MIR223 ,  GAGACTG_MIR452 ,  MAX_01 ,  IPF1_Q4 ,  TAAYNRNNTCC_UNKNOWN ,  GGTGAAG_MIR412 ,  GGGAGGRR_MAZ_Q6 ,  CEBPDELTA_Q6 ,  YY1_Q6 ,  ETS2_B ,  GTTTGTT_MIR495 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  OCT1_03 ,  AHR_Q5 ,  E2F1_Q3_01 ,  AP2_Q3 ,  GACTGTT_MIR212_MIR132 ,  KCCGNSWTTT_UNKNOWN ,  PTF1BETA_Q6 ,  HLF_01 ,  NMYC_01 ,  TTGCCAA_MIR182 ,  WGGAATGY_TEF1_Q6 ,  CEBP_C ,  YY1_02 ,  CTGCAGY_UNKNOWN ,  GTGGGTGK_UNKNOWN ,  E2F1_Q3 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  E2F_Q3 ,  ACCTGTTG_UNKNOWN ,  ETS1_B

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Cytogenetic Map:

6q21

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