QuickView for FosB (gene)

Gene Symbol:

FOSB Homo sapiens

Full name:

FosB proto-oncogene, AP-1 transcription factor subunit

Synonyms:

AP-1, G0S3, GOS3, GOSB, protein fosB, FBJ murine osteosarcoma viral oncogene homolog B, FosB proto-oncogene, AP-1 trancription factor subunit, G0/G1 switch regulatory protein 3, activator protein 1

Genomic Location:

Chr 19: 50663093-50670276

Description:

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternat...

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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TFIIA_Q6 ,  SRF_01 ,  CREB_Q4_01 ,  EFC_Q6 ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  TTCNRGNNNNTTC_HSF_Q6 ,  AAAYWAACM_HFH4_01 ,  GTGACTT_MIR224 ,  ATF4_Q2 ,  CYTAGCAAY_UNKNOWN ,  CREB_Q4 ,  ACTGTGA_MIR27A_MIR27B ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  ATF_B ,  CREBP1_Q2 ,  GGTGTGT_MIR329 ,  CEBPDELTA_Q6 ,  STAT3_02 ,  ACATTCC_MIR1_MIR206 ,  GGGYGTGNY_UNKNOWN ,  GTGACGY_E4F1_Q6 ,  YYCATTCAWW_UNKNOWN ,  NFY_Q6_01 ,  CEBP_01 ,  ATF_01 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  TGCGCANK_UNKNOWN ,  HNF3_Q6 ,  CREB_02 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  E4F1_Q6 ,  AHR_Q5 ,  S8_01 ,  TGTTTGY_HNF3_Q6 ,  ATACTGT_MIR144 ,  CAGCAGG_MIR370 ,  AATGTGA_MIR23A_MIR23B ,  CHX10_01 ,  AACATTC_MIR4093P ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  CREB_Q2 ,  TAL1BETAITF2_01 ,  SRF_Q5_01 ,  CCGNMNNTNACG_UNKNOWN ,  SP1_Q6_01 ,  AACTTT_UNKNOWN ,  CCAWWNAAGG_SRF_Q4 ,  CREB_Q2_01 ,  CREB_01 ,  SRF_C ,  TATTATA_MIR374 ,  TAXCREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-410

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Cytogenetic Map:

19q13.32

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