QuickView for Foxp2 (gene)

Gene Symbol:

FOXP2 Homo sapiens

Full name:

forkhead box P2

Synonyms:

CAGH44, SPCH1, TNRC10, forkhead box protein P2, CAG repeat protein 44, forkhead/winged-helix transcription factor, trinucleotide repeat containing 10, trinucleotide repeat-containing gene 10 protein

Genomic Location:

Chr 7: 113842288-114118328

Description:

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may ...

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This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  POU6F1_01 ,  AACWWCAANK_UNKNOWN ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  PAX4_04 ,  OCT1_05 ,  SMTTTTGT_UNKNOWN ,  HNF3ALPHA_Q6 ,  TGIF_01 ,  TFIIA_Q6 ,  CEBPA_01 ,  HNF1_01 ,  TAL1ALPHAE47_01 ,  TTANTCA_UNKNOWN ,  OCT1_04 ,  TGGNNNNNNKCCAR_UNKNOWN ,  FOX_Q2 ,  HFH3_01 ,  NFAT_Q6 ,  SREBP1_02 ,  TGANNYRGCA_TCF11MAFG_01 ,  HOXA4_Q2 ,  AP3_Q6 ,  FOXO4_01 ,  GATA_Q6 ,  YRTCANNRCGC_UNKNOWN ,  OCT_Q6 ,  POU3F2_01 ,  SYATTGTG_UNKNOWN ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  CATTGTYY_SOX9_B1 ,  NKX3A_01 ,  GCANCTGNY_MYOD_Q6 ,  AAAYWAACM_HFH4_01 ,  AAANWWTGC_UNKNOWN ,  HFH1_01 ,  CIZ_01 ,  LXR_DR4_Q3 ,  EVI1_04 ,  YATTNATC_UNKNOWN ,  HP1SITEFACTOR_Q6 ,  ARP1_01 ,  AREB6_04 ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  TTF1_Q6 ,  NKX22_01 ,  MYB_Q5_01 ,  CTCNANGTGNY_UNKNOWN ,  MAF_Q6 ,  OCT1_Q5_01 ,  GATA1_04 ,  WHN_B ,  ACTGTGA_MIR27A_MIR27B ,  TCF4_Q5 ,  COMP1_01 ,  WTGAAAT_UNKNOWN ,  TATAAA_TATA_01 ,  AR_Q6 ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  RGAANNTTC_HSF1_01 ,  CEBPB_01 ,  TAL1BETAE47_01 ,  LEF1_Q6 ,  DBP_Q6 ,  PAX4_02 ,  PAX2_01 ,  FOXO3_01 ,  CAGGTA_AREB6_01 ,  RP58_01 ,  FREAC3_01 ,  YY1_01 ,  HNF4_Q6 ,  EVI1_05 ,  CCAWYNNGAAR_UNKNOWN ,  HNF3B_01 ,  FOXJ2_01 ,  TGCTGAY_UNKNOWN ,  PITX2_Q2 ,  SRF_Q4 ,  LMO2COM_02 ,  OCT1_03 ,  NKX61_01 ,  NKX25_02 ,  FOXO1_01 ,  RAAGNYNNCTTY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  HFH4_01 ,  GCCNNNWTAAR_UNKNOWN ,  POU1F1_Q6 ,  MEIS1_01 ,  TGTTTGY_HNF3_Q6 ,  HFH8_01 ,  SOX5_01 ,  OCT1_06 ,  PTF1BETA_Q6 ,  YCATTAA_UNKNOWN ,  AR_Q2 ,  GFI1_01 ,  EN1_01 ,  OCT1_02 ,  FREAC2_01 ,  CEBP_Q3 ,  CHX10_01 ,  POU3F2_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  AAAYRNCTG_UNKNOWN ,  CART1_01 ,  PIT1_Q6 ,  GATA4_Q3 ,  MSX1_01 ,  RTTTNNNYTGGM_UNKNOWN ,  GATA1_05 ,  MEF2_03 ,  WTTGKCTG_UNKNOWN ,  IRF7_01 ,  CP2_02 ,  TAL1BETAITF2_01 ,  SRF_Q5_01 ,  TGATTTRY_GFI1_01 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  RNTCANNRNNYNATTW_UNKNOWN ,  WCAANNNYCAG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  MMEF2_Q6 ,  CDC5_01 ,  FOXM1_01 ,  SRY_02 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  YNGTTNNNATT_UNKNOWN ,  YAATNANRNNNCAG_UNKNOWN ,  TGACATY_UNKNOWN ,  DR4_Q2 ,  PAX2_02 ,  HNF1_Q6 ,  RYTAAWNNNTGAY_UNKNOWN ,  CEBPGAMMA_Q6 ,  FREAC4_01 ,  FOXO4_02 ,  SRF_C ,  ACATATC_MIR190 ,  TCF11_01 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-27

Cytogenetic Map:

7q31.1

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