QuickView for Furin (gene)

Gene Symbol:

FURIN Homo sapiens

Full name:

furin, paired basic amino acid cleaving enzyme

Synonyms:

FUR, PACE, PCSK3, SPC1, furin, FES upstream region, FURIN/ADAMTS1 fusion, dibasic processing enzyme, furin, membrane associated receptor protein, paired basic amino acid residue-cleaving enzyme, proprotein convertase subtilisin/kexin type 3

Genomic Location:

Chr 15: 89212889-89227691

Description:

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and...

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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  TGANTCA_AP1_C ,  GATA1_03 ,  ETS_Q4 ,  RYTTCCTG_ETS2_B ,  VDR_Q3 ,  CTATGCA_MIR153 ,  TEL2_Q6 ,  LYF1_01 ,  TAAYNRNNTCC_UNKNOWN ,  AAGCAAT_MIR137 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  TGCAAAC_MIR452 ,  ETS2_B ,  GTAAGAT_MIR200A ,  ATGCTGC_MIR103_MIR107 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ACCAAAG_MIR9 ,  GACAATC_MIR219 ,  YTTCCNNNGGAMR_UNKNOWN ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  GATA1_02 ,  YCATTAA_UNKNOWN ,  GTGCCTT_MIR506 ,  GGCACTT_MIR519E ,  GGCAGCT_MIR22 ,  ELK1_01 ,  CCAGGGG_MIR331 ,  CTGAGCC_MIR24 ,  AGGGCAG_MIR18A ,  CCATCCA_MIR432 ,  P300_01 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ETS1_B ,  CACTTTG_MIR520G_MIR520H ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

15q26.1

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