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QuickView for Fusidic Acid (compound)
PubChem
| Name: | Fusidic Acid |
|---|---|
| PubChem Compound ID: | 11466473 |
| Description: | An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis. |
| Molecular formula: | C31H48O6 |
| Molecular weight: | 516.709 g/mol |
DrugBank
Identification
| Name: | Fusidic Acid |
|---|---|
| Name (isomeric): | DB02703 |
| Drug Type: | small molecule |
| Description: | An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis. |
| Synonyms: |
Fucidic acid; Fucidate; Fusidate Sodium; Fucidate Sodium; Diethanolamine fusidate; Fusidate
|
| Brand: | Ramycin, Fucidin acid, Fucidin, Fucidin Cream 2%, Fucithalmic, Fusidine, Fucidine |
| Brand name mixture: | Fucibet(Fusidic acid + betamethasone), Fucicort(Fusidic acid + hydrocortisone) |
| Category: | Protein Synthesis Inhibitors, Anti-Bacterial Agents, Antibacterial Agents |
| CAS number: | 6990-06-3 |
Pharmacology
| Indication: | For the treatment of bacterial infections. |
|---|---|
| Pharmacology: | Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections. |
| Mechanism of Action: | Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes. |
| Absorption: | Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose. |
| Protein binding: | 97 to 99% |
| Biotransformation: | Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite. |
| Half Life: | Approximately 5 to 6 hours in adults. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
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Targets
Transporters
