QuickView for Fzd7 (gene)

Gene Symbol:

FZD7 Homo sapiens

Full name:

frizzled class receptor 7

Synonyms:

FzE3, frizzled-7, Frizzled, drosophila, homolog of, 7, frizzled 7, seven transmembrane spanning receptor, frizzled family receptor 7, frizzled homolog 7, fz-7, hFz7

Genomic Location:

Chr 2: 202607555-202611405

Description:

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail wit...

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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  HNF4ALPHA_Q6 ,  GCATTTG_MIR105 ,  AAANWWTGC_UNKNOWN ,  AACTGGA_MIR145 ,  WGTTNNNNNAAA_UNKNOWN ,  ACTTTAT_MIR1425P ,  CTTTGA_LEF1_Q2 ,  TTF1_Q6 ,  ACTGTGA_MIR27A_MIR27B ,  GGGAGGRR_MAZ_Q6 ,  ACATTCC_MIR1_MIR206 ,  CAGGGTC_MIR504 ,  GGGCGGR_SP1_Q6 ,  E4F1_Q6 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  AACATTC_MIR4093P ,  CCTGCTG_MIR214 ,  TTGTTT_FOXO4_01 ,  YTAATTAA_LHX3_01 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-504

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Cytogenetic Map:

2q33.1

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