QuickView for G3BP1 (gene)

Gene Symbol:

G3BP1 Homo sapiens

Full name:

G3BP stress granule assembly factor 1

Synonyms:

G3BP, HDH-VIII, ras GTPase-activating protein-binding protein 1, ATP-dependent DNA helicase VIII, DNA helicase VIII, G3BP-1, GAP SH3 domain-binding protein 1, GAP binding protein, GTPase activating protein (SH3 domain) binding protein 1, Ras-GTPase-activating protein SH3-domain-binding protein, RasGAP-associated endoribonuclease G3BP

Genomic Location:

Chr 5: 151131669-151165108

Description:

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically t...

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This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TTANTCA_UNKNOWN ,  NFKAPPAB_01 ,  AP2ALPHA_01 ,  NFKAPPAB65_01 ,  AP1_01 ,  GGGCGGR_SP1_Q6 ,  GTGCCTT_MIR506 ,  CREL_01 ,  CTTTGT_LEF1_Q2 ,  NFKB_Q6_01 ,  AACTTT_UNKNOWN ,  NFKB_Q6 ,  NFKB_C ,  GGGNNTTTCC_NFKB_Q6_01

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miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

5q33.1

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