QuickView for GABPA (gene)

Gene Symbol:

GABPA Homo sapiens

Full name:

GA binding protein transcription factor alpha subunit

Synonyms:

E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07, GA-binding protein alpha chain, GA binding protein transcription factor alpha subunit 60kDa, GABP subunit alpha, human nuclear respiratory factor-2 subunit alpha, nuclear respiratory factor 2 alpha subunit, nuclear respiratory factor 2 subunit alpha, transcription factor E4TF1-60

Genomic Location:

Chr 21: 26029570-26066213

Description:

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit a...

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This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGACCTY_ERR1_Q2 ,  ATACCTC_MIR202 ,  GTCAGGA_MIR378 ,  ATGTTAA_MIR302C ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  TGACCTTG_SF1_Q6 ,  STAT5A_02

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-490 ,  Predicted Gene Targets for miR-378

Cytogenetic Map:

21q21.3

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