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QuickView for GABRB3 (gene)


Gene Symbol:
GABRB3 Homo sapiens Homo sapiens
Full name:
gamma-aminobutyric acid type A receptor beta3 subunit
Synonyms:
ECA5, EIEE43, gamma-aminobutyric acid receptor subunit beta-3, GABA-alpha receptor beta-2 subunit, GABAA receptor beta-3 subunit, gamma-aminobutyric acid (GABA) A receptor, beta 3, gamma-aminobutyric acid A receptor beta 3
Genomic Location:
Chr 15: 24339786-24570020
Description:
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two oth...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 15
15q12





GO Molecular Function

transmitter-gated ion channel activity | neurotransmitter receptor activity | anion transmembrane transporter activity | GABA-A receptor activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | chloride channel activity | inorganic anion transmembrane transporter activity | GABA-gated chloride ion channel activity | chloride transmembrane transporter activity | signaling receptor activity | transporter activity | identical protein binding | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | GABA receptor activity | protein binding | anion channel activity | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

transmitter-gated ion channel activity | regulation of programmed cell death | establishment of localization | negative regulation of neuron death | anion transmembrane transporter activity | negative regulation of cellular process | cell differentiation | nervous system development | neurogenesis | generation of neurons | sensory perception of mechanical stimulus | regulation of neuron death | cellular process | gamma-aminobutyric acid signaling pathway | localization | passive transmembrane transporter activity | chemical synaptic transmission | neuron development | anion transport | negative regulation of apoptotic process | regulation of cellular process | regulation of apoptotic process | transmembrane transporter activity | ligand-gated ion channel activity | cellular response to organonitrogen compound | chloride transmembrane transport | response to stimulus | ion gated channel activity | roof of mouth development | chloride channel activity | chloride transport | inorganic anion transport | inner ear receptor cell differentiation | cellular response to organic cyclic compound | G-protein coupled receptor signaling pathway | inorganic anion transmembrane transporter activity | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | GABA-gated chloride ion channel activity | regulation of membrane potential | response to nitrogen compound | negative regulation of neuron apoptotic process | system development | multicellular organism development | inner ear receptor cell development | chloride transmembrane transporter activity | ion transmembrane transport | mechanoreceptor differentiation | cellular response to ammonium ion | regulation of postsynaptic membrane potential | nervous system process | synaptic signaling | response to ammonium ion | ion transmembrane transporter activity | innervation | extracellular ligand-gated ion channel activity | sensory organ development | cell communication | regulation of neuron apoptotic process | sensory perception of sound | inner ear development | response to histamine | neuron differentiation | inhibitory postsynaptic potential | response to organic substance | anion transmembrane transport | anatomical structure development | cell surface receptor signaling pathway | anion channel activity | negative regulation of programmed cell death | ear development | animal organ development | nerve development | sensory perception | transmembrane transport | signaling | response to organic cyclic compound | cell development | channel activity | developmental process | cochlea development | response to organonitrogen compound | ion channel activity | cellular response to histamine | ion transport | cellular response to organic substance | regulation of cell death | negative regulation of cell death | substrate-specific channel activity | signal transduction | multicellular organismal process

GO Cellular Component

integral component of membrane | synapse | neuron projection | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | synaptic membrane | cytoplasm | intracellular organelle | receptor complex | protein-containing complex | cell projection | postsynaptic membrane | postsynapse | plasma membrane | GABA receptor complex | chloride channel complex | vesicle | integral component of plasma membrane | membrane-bounded organelle | organelle | vesicle membrane | cell periphery | transmembrane transporter complex | ion channel complex | intracellular vesicle | intracellular | cell junction | membrane | cytoplasmic vesicle membrane | GABA-A receptor complex | intrinsic component of plasma membrane