QuickView for GAD65;jsessionid=D642737D9EDD5E1769367D090DE6D195;jsessionid=A80798C1943C246CFE0BA369C8DB66A1 (gene)

Gene Symbol:

GAD2 Homo sapiens

Full name:

glutamate decarboxylase 2

Synonyms:

GAD65, glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase-2 (pancreas), glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa), glutamate decarboxylase 65 kDa isoform

Genomic Location:

Chr 10: 26545600-26633493

Description:

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identif...

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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGTG_MIR128A_MIR128B ,  RYTTCCTG_ETS2_B ,  RGAANNTTC_HSF1_01 ,  TGTATGA_MIR4853P ,  CAGGTG_E12_Q6 ,  CAGNYGKNAAA_UNKNOWN ,  HSF1_01 ,  GTATGAT_MIR154_MIR487 ,  TGCTGAY_UNKNOWN ,  AHR_Q5 ,  NKX61_01 ,  AAAGACA_MIR511 ,  HSF_Q6 ,  TTGTTT_FOXO4_01 ,  ER_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-485-3p

Cytogenetic Map:

10p12.1

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