QuickView for GALNT8;jsessionid=DF4BF83FABAE68907919B9421139EA4A (gene)

Gene Symbol:

GALNT8 Homo sapiens

Full name:

polypeptide N-acetylgalactosaminyltransferase 8

Synonyms:

GALNAC-T8, probable polypeptide N-acetylgalactosaminyltransferase 8, GalNAc transferase 8, UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 8, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8), polypeptide GalNAc transferase 8, pp-GaNTase 8, protein-UDP acetylgalactosaminyltransferase 8

Genomic Location:

Chr 12: 4700013-4752153

Description:

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal...

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This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression.

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Orthologs:

Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

12p13.32

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