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QuickView for GAPDH (gene)


Gene Symbol:
GAPDH Homo sapiens Homo sapiens
Full name:
glyceraldehyde-3-phosphate dehydrogenase
Synonyms:
G3PD, GAPD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase, OCAS, p38 component, Oct1 coactivator in S phase, 38 Kd component, aging-associated gene 9 protein, epididymis secretory sperm binding protein Li 162eP, peptidyl-cysteine S-nitrosylase GAPDH
Genomic Location:
Chr 12: 6513918-6517797
Description:
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative pho...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGANTCA_AP1_C USF_Q6 ARNT_01 TGANNYRGCA_TCF11MAFG_01 E2F1_Q4_01 CACGTG_MYC_Q2 E2F4DP1_01 GCANCTGNY_MYOD_Q6 MAX_01 E2F_Q6_01
Cytogenetic Map:
chr 12
12p13.31





GO Molecular Function

aspartic-type endopeptidase inhibitor activity | endopeptidase inhibitor activity | NADP binding | cofactor binding | peptidyl-cysteine S-nitrosylase activity | disordered domain specific binding | nucleotide binding | enzyme inhibitor activity | coenzyme binding | molecular function regulator | catalytic activity | protein domain specific binding | cytoskeletal protein binding | identical protein binding | organic cyclic compound binding | protein binding | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | NAD binding | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | transferase activity | microtubule binding | tubulin binding | peptidase inhibitor activity | enzyme regulator activity | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

positive regulation of cell killing | purine ribonucleotide metabolic process | purine ribonucleoside monophosphate biosynthetic process | aspartic-type endopeptidase inhibitor activity | endopeptidase inhibitor activity | response to cytokine | nucleoside phosphate catabolic process | positive regulation of apoptotic process | protein stabilization | glycolytic process | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | defense response to other organism | regulation of autophagy | neuron death | negative regulation of cellular process | glucose metabolic process | microtubule cytoskeleton organization | defense response | nicotinamide nucleotide biosynthetic process | generation of precursor metabolites and energy | organophosphate catabolic process | killing by host of symbiont cells | positive regulation of protein secretion | microtubule-based process | negative regulation of proteolysis | interaction with symbiont | cellular process | organic substance catabolic process | peptidyl-cysteine S-nitrosylase activity | nucleotide metabolic process | NADH regeneration | positive regulation of killing of cells of other organism | ribose phosphate metabolic process | purine nucleotide biosynthetic process | regulation of proteolysis | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | carbohydrate catabolic process | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | cellular response to interferon-gamma | regulation of peptide secretion | response to stimulus | enzyme inhibitor activity | defense response to fungus | purine nucleotide metabolic process | monocarboxylic acid metabolic process | response to stress | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | programmed cell death | positive regulation of cytokine secretion | cellular nitrogen compound metabolic process | regulation of macroautophagy | carbohydrate derivative biosynthetic process | regulation of protein transport | negative regulation of metabolic process | cofactor metabolic process | protein modification process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | nucleobase-containing compound catabolic process | molecular function regulator | nucleotide biosynthetic process | positive regulation of peptide secretion | NADH metabolic process | apoptotic process | response to external biotic stimulus | ATP biosynthetic process | nitrogen compound metabolic process | regulation of protein stability | coenzyme biosynthetic process | negative regulation of catalytic activity | regulation of peptidase activity | phosphorus metabolic process | ribonucleoside monophosphate biosynthetic process | regulation of catalytic activity | regulation of killing of cells of other organism | positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction | negative regulation of peptidase activity | regulation of gene expression | cell killing | NAD biosynthetic process | positive regulation of secretion | organophosphate metabolic process | modification of morphology or physiology of other organism | hexose biosynthetic process | nucleotide phosphorylation | cofactor biosynthetic process | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | neuron apoptotic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | carbohydrate biosynthetic process | cellular response to cytokine stimulus | biosynthetic process | pyruvate metabolic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | purine ribonucleotide biosynthetic process | carbohydrate metabolic process | nucleotide catabolic process | nucleoside triphosphate biosynthetic process | phosphate-containing compound metabolic process | response to fungus | regulation of cellular metabolic process | antimicrobial humoral immune response mediated by antimicrobial peptide | humoral immune response | regulation of protein metabolic process | aromatic compound catabolic process | positive regulation of establishment of protein localization | positive regulation of transport | drug metabolic process | carboxylic acid metabolic process | disruption by host of symbiont cells | regulation of cytokine secretion | pyridine nucleotide biosynthetic process | glycolytic process through glucose-6-phosphate | antimicrobial humoral response | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | protein metabolic process | regulation of establishment of protein localization | response to organic substance | nucleoside diphosphate metabolic process | killing of cells of other organism | peptidyl-cysteine S-nitrosylation | metabolic process | hexose metabolic process | oxidation-reduction process | regulation of secretion | positive regulation of cell death | gluconeogenesis | immune response | nucleobase-containing compound metabolic process | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | regulation of protein secretion | positive regulation of programmed cell death | glycolytic process through fructose-6-phosphate | protein nitrosylation | ATP generation from ADP | cytoskeleton organization | negative regulation of translation | response to interferon-gamma | positive regulation of cytokine production | pyruvate biosynthetic process | positive regulation of protein transport | peptidyl-cysteine S-trans-nitrosylation | negative regulation of protein metabolic process | ADP metabolic process | negative regulation of molecular function | ribose phosphate biosynthetic process | organic acid metabolic process | peptidase inhibitor activity | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | glucose catabolic process | regulation of endopeptidase activity | response to biotic stimulus | organelle organization | nicotinamide nucleotide metabolic process | cellular protein modification process | NAD metabolic process | carbohydrate derivative metabolic process | regulation of transport | innate immune response | canonical glycolysis | heterocycle metabolic process | negative regulation of hydrolase activity | immune system process | cellular metabolic process | ATP metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | oxidoreductase activity | regulation of translation | nucleoside diphosphate phosphorylation | response to other organism | nucleoside monophosphate biosynthetic process | negative regulation of endopeptidase activity | macromolecule metabolic process

GO Cellular Component

GAIT complex | intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | plasma membrane | nuclear envelope | ribonucleoprotein complex | vesicle | lipid droplet | perinuclear region of cytoplasm | extracellular exosome | microtubule cytoskeleton | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | cytosol | cytoskeleton | intracellular | membrane