QuickView for GART (gene)
- Gene Symbol:
- GART
Homo sapiens - Full name:
- phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
- Synonyms:
- AIRS, GARS, GARTF, PAIS, PGFT, PRGS, trifunctional purine biosynthetic protein adenosine-3, GAR transformylase, GARS-AIRS-GART, glycinamide ribonucleotide formyltransferase, glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase
- Genomic Location:
- Chr 21: 33798139-33836286
- Description:
-
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in tw...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
21q22.11
| Transcripts Names |
|---|
| NM_000819 |
| NM_175085 |
| NM_001136005 |
| NM_001136006 |
| XM_006723989 |
| XM_006723990 |
| XM_005260941 |
| XM_011529526 |
GO Molecular Function
cation binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | ligase activity, forming carbon-nitrogen bonds | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | phosphoribosylformylglycinamidine cyclo-ligase activity | purine ribonucleoside triphosphate binding | ligase activity | phosphoribosylglycinamide formyltransferase activity | transferase activity | hydroxymethyl-, formyl- and related transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | phosphoribosylamine-glycine ligase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
brain development | purine ribonucleotide metabolic process | purine ribonucleoside monophosphate biosynthetic process | glycine metabolic process | pteridine-containing compound biosynthetic process | nervous system development | tetrahydrofolate metabolic process | cellular process | nucleotide metabolic process | serine family amino acid metabolic process | ribose phosphate metabolic process | purine nucleotide biosynthetic process | ribonucleotide metabolic process | response to inorganic substance | folic acid-containing compound biosynthetic process | cellular amino acid metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | folic acid-containing compound metabolic process | head development | tetrahydrofolate biosynthetic process | response to stimulus | purine nucleotide metabolic process | metencephalon development | cellular nitrogen compound biosynthetic process | purine nucleobase biosynthetic process | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cofactor metabolic process | cellular biosynthetic process | pteridine-containing compound metabolic process | nucleotide biosynthetic process | regulation of neurotransmitter levels | system development | brainstem development | nitrogen compound metabolic process | coenzyme biosynthetic process | multicellular organism development | phosphorus metabolic process | ribonucleoside monophosphate biosynthetic process | cerebellum development | telencephalon development | organophosphate metabolic process | cofactor biosynthetic process | pigment biosynthetic process | small molecule metabolic process | cellular amide metabolic process | adenine metabolic process | nucleobase-containing small molecule metabolic process | neurotransmitter metabolic process | biosynthetic process | aromatic compound biosynthetic process | hindbrain development | purine ribonucleotide biosynthetic process | phosphate-containing compound metabolic process | cerebral cortex development | drug metabolic process | carboxylic acid metabolic process | response to organic substance | 'de novo' IMP biosynthetic process | anatomical structure development | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | pigment metabolic process | animal organ development | forebrain development | pallium development | amide biosynthetic process | adenine biosynthetic process | IMP biosynthetic process | ribose phosphate biosynthetic process | organic acid metabolic process | developmental process | purine nucleobase metabolic process | carbohydrate derivative metabolic process | cellular modified amino acid metabolic process | heterocycle metabolic process | central nervous system development | cellular metabolic process | IMP metabolic process | nucleoside monophosphate biosynthetic process | multicellular organismal process
GO Cellular Component
cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular
