QuickView for GATA3 (gene)
- Gene Symbol:
- GATA3
Homo sapiens - Full name:
- GATA binding protein 3
- Synonyms:
- HDR, HDRS, trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3
- Genomic Location:
- Chr 10: 8136673-8157170
- Description:
-
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-101 , Predicted Gene Targets for miR-135 , Predicted Gene Targets for miR-144 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-369-3p , Predicted Gene Targets for miR-381 , Predicted Gene Targets for miR-433-3p , Predicted Gene Targets for miR-374 , Predicted Gene Targets for miR-504 , Predicted Gene Targets for miR-544
- Cytogenetic Map:
-
10p14
GO Molecular Function
sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | HMG box domain binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | enhancer binding | cation binding | transcription factor activity, RNA polymerase II transcription factor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | signaling receptor binding | cytokine receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein domain specific binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | growth factor receptor binding | transcription coregulator activity | interleukin-2 receptor binding | metal ion binding | heterocyclic compound binding
GO Biological Process
positive regulation of immune response | protein modification by small protein removal | RNA metabolic process | transcription by RNA polymerase II | regulation of T cell mediated immunity | regulation of epithelial cell differentiation involved in kidney development | adaptive immune response | regulation of thyroid hormone generation | response to radiation | cell morphogenesis | inner ear morphogenesis | nephron tubule formation | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to virus | positive regulation of epithelial tube formation | CD4-positive, alpha-beta T cell differentiation | negative regulation of embryonic development | response to cytokine | positive regulation of cellular component organization | cell motility | pharyngeal system development | regulation of neurogenesis | CD4-positive, alpha-beta T cell activation | neuron projection morphogenesis | immune response-regulating signaling pathway | developmental process involved in reproduction | mesonephric tubule formation | intracellular signal transduction | proteolysis | regulation of cell development | regulation of localization | catechol-containing compound metabolic process | otic vesicle development | morphogenesis of an epithelium | regulation of ureteric bud formation | positive regulation of embryonic development | gonad development | regulation of programmed cell death | negative regulation of cell proliferation involved in mesonephros development | hormone secretion | erythrocyte homeostasis | eye development | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | myeloid cell differentiation | neuron migration | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | positive regulation of lymphocyte activation | regulation of histone H3-K14 acetylation | cellular response to interferon-alpha | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | T cell receptor signaling pathway | ureteric bud formation | defense response | negative regulation of fat cell differentiation | T-helper 2 cell differentiation | nervous system development | interleukin-4 secretion | response to drug | regulation of hematopoietic progenitor cell differentiation | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of T-helper 2 cell cytokine production | negative regulation of cell proliferation involved in kidney development | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | response to antibiotic | negative regulation of DNA metabolic process | phenol-containing compound metabolic process | canonical Wnt signaling pathway involved in metanephric kidney development | positive regulation of T cell differentiation | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | secretion | negative regulation of inflammatory response | lymphocyte differentiation | regulation of cytokine biosynthetic process | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | chromatin organization | cell maturation | protein transport | lymphoid progenitor cell differentiation | heart morphogenesis | negative regulation of signaling | developmental growth | positive regulation of immune effector process | neuron development | reproductive system development | canonical Wnt signaling pathway | positive regulation of adaptive immune response | TOR signaling | regulation of embryonic development | immune system development | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | macromolecule localization | regulation of histone modification | hemostasis | negative regulation of apoptotic process | axon guidance | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | type IV hypersensitivity | positive regulation of thyroid hormone generation | regulation of neuron projection development | transcription factor activity, RNA polymerase II transcription factor binding | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of histone H3-K9 acetylation | regulation of fat cell differentiation | regulation of cell differentiation | autonomic nervous system development | negative regulation of cell motility | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | T cell differentiation involved in immune response | negative regulation of fibroblast growth factor receptor signaling pathway | regulation of nephron tubule epithelial cell differentiation | type 2 immune response | organic cyclic compound metabolic process | regulation of type 2 immune response | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | positive regulation of T cell cytokine production | cellular aromatic compound metabolic process | positive regulation of interleukin-4 production | cellular component organization | protein deubiquitination | regulation of establishment of cell polarity | urogenital system development | positive regulation of epithelial cell migration | T cell activation | nephron tubule morphogenesis | development of primary sexual characteristics | regulation of peptide secretion | negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation | regulation of histone methylation | response to stimulus | negative regulation of epithelial cell apoptotic process | cardiac right ventricle morphogenesis | thymus development | positive regulation of interleukin-5 secretion | cell morphogenesis involved in neuron differentiation | nephric duct morphogenesis | alpha-beta T cell activation involved in immune response | embryonic epithelial tube formation | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of CD4-positive, alpha-beta T cell activation | response to stress | neuron projection guidance | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of mammary gland epithelial cell proliferation | tube morphogenesis | negative regulation of interferon-gamma production | positive regulation of cell-cell adhesion | hematopoietic progenitor cell differentiation | regulation of epithelial cell differentiation | inflammatory response to antigenic stimulus | phosphatidylinositol-mediated signaling | regulation of transcription regulatory region DNA binding | positive regulation of cell activation | epithelial tube formation | reproduction | secretion by cell | response to alcohol | positive regulation of cytokine secretion | cardiac ventricle morphogenesis | positive regulation of ureteric bud formation | cellular nitrogen compound metabolic process | positive regulation of T cell activation | immune response-activating signal transduction | regulation of DNA binding | catecholamine biosynthetic process | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | kidney development | embryo development | macromolecule modification | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of lymphocyte differentiation | regulation of establishment or maintenance of cell polarity | myeloid cell homeostasis | response to ethanol | leukocyte migration | blood coagulation | regulation of nucleic acid-templated transcription | T-helper cell differentiation | positive regulation of peptide secretion | leukocyte differentiation | locomotion | organic hydroxy compound metabolic process | response to BMP | parathyroid hormone secretion | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | regulation of interleukin-4 production | negative regulation of DNA demethylation | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | interleukin-4 production | ureteric bud development | Wnt signaling pathway | interferon-gamma secretion | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | parathyroid gland development | leukocyte mediated immunity | positive regulation of protein kinase B signaling | embryonic hemopoiesis | kidney morphogenesis | regulation of hormone levels | regulation of CD4-positive, alpha-beta T cell differentiation | wound healing | positive regulation of chromosome organization | regulation of T cell activation | regulation of hematopoietic stem cell differentiation | regulation of neuron differentiation | regulation of gene expression | kidney epithelium development | axon development | positive regulation of secretion | organic substance transport | myeloid leukocyte differentiation | regulation of fibroblast growth factor receptor signaling pathway | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of lymphocyte activation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of cell migration | lymphocyte migration | peptide transport | cytokine-mediated signaling pathway | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | regulation of cellular response to X-ray | regulation of cellular component movement | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | positive regulation of interleukin-13 production | regulation of endothelial cell apoptotic process | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | axonogenesis | positive regulation of cell differentiation | regulation of endothelial cell migration | negative regulation of mammary gland epithelial cell proliferation | regulation of T cell cytokine production | homeostasis of number of cells | response to interferon-alpha | positive regulation of cell migration | cellular response to cytokine stimulus | positive regulation of histone H3-K9 acetylation | biosynthetic process | aortic valve morphogenesis | regulation of hormone metabolic process | ureter maturation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | T cell activation involved in immune response | mesonephric epithelium development | norepinephrine metabolic process | regulation of histone H3-K27 methylation | nephric duct formation | inositol lipid-mediated signaling | response to toxic substance | endocrine system development | regulation of epithelial cell apoptotic process | cell morphogenesis involved in differentiation | response to gamma radiation | mesonephros development | post-embryonic development | mesenchymal to epithelial transition | sensory organ development | response to estrogen | chordate embryonic development | peptide secretion | endocrine process | cell communication | regulation of cellular metabolic process | chromatin remodeling | sympathetic nervous system development | regulation of neuron apoptotic process | metanephros development | renal tubule development | regulation of alpha-beta T cell differentiation | semi-lunar valve development | nephric duct development | humoral immune response | inflammatory response | T cell mediated immunity | cell activation involved in immune response | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | regulation of histone H3-K4 methylation | heart development | negative regulation of interleukin-2 production | homeostatic process | positive regulation of establishment of protein localization | regulation of locomotion | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | regulation of stem cell differentiation | positive regulation of protein acetylation | renal system development | positive regulation of transport | regulation of cellular response to growth factor stimulus | coagulation | embryonic morphogenesis | nephron development | lymphocyte activation | positive regulation of molecular function | acute inflammatory response to antigenic stimulus | regulation of cytokine secretion | neuron differentiation | cytokine production | embryonic organ morphogenesis | T cell differentiation | cellular response to interleukin-4 | development of primary male sexual characteristics | ureteric bud morphogenesis | activation of immune response | heart valve development | ventricular septum development | negative regulation of epithelial cell proliferation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | cardiac ventricle development | positive regulation of type 2 immune response | positive regulation of protein modification process | T cell selection | response to organic substance | gland development | T cell differentiation in thymus | tissue morphogenesis | regulation of hemopoiesis | catecholamine metabolic process | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | positive regulation of peptidyl-lysine acetylation | phosphatidylinositol 3-kinase signaling | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | cell fate commitment | cytokine secretion | positive regulation of histone H3-K14 acetylation | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | developmental maturation | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | male gonad development | positive regulation of cytokine production involved in immune response | ear development | regulation of interleukin-5 production | amide transport | regulation of secretion | morphogenesis of embryonic epithelium | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | hormone transport | nucleobase-containing compound metabolic process | neuron projection development | thymic T cell selection | heart valve morphogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | positive regulation of histone modification | gene expression | regulation of cell activation | negative regulation of cellular component movement | regulation of protein secretion | alpha-beta T cell activation | positive regulation of interleukin-5 production | protein modification by small protein conjugation or removal | norepinephrine biosynthetic process | regulation of chromosome organization | antigen receptor-mediated signaling pathway | positive regulation of binding | establishment of protein localization | transcription, DNA-templated | positive regulation of cytokine production | positive regulation of endothelial cell migration | cell activation | positive regulation of T cell mediated immunity | positive regulation of protein transport | camera-type eye development | anatomical structure formation involved in morphogenesis | uterus development | negative regulation of cell cycle | regulation of epithelial cell migration | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | positive regulation of DNA binding | protein localization | regulation of epithelial cell proliferation | cellular protein metabolic process | regulation of cytokine production | anatomical structure morphogenesis | pro-T cell differentiation | cellular macromolecule biosynthetic process | response to biotic stimulus | reproductive structure development | regulation of nervous system development | regulation of developmental process | developmental process | ureter development | organelle organization | erythrocyte differentiation | cardiac septum development | cellular protein modification process | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of histone acetylation | regulation of transport | positive regulation of transcription, DNA-templated | aortic valve development | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of interleukin-13 secretion | innate immune response | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | cell fate determination | signal release | cochlea development | transcription coregulator activity | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | cardiac chamber development | heterocycle metabolic process | tube formation | in utero embryonic development | positive regulation of metabolic process | chromosome organization | cellular response to BMP stimulus | mast cell differentiation | regulation of cell projection organization | acute inflammatory response | regulation of interferon-gamma production | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | protein secretion | positive regulation of cell motility | negative regulation of cell death | circulatory system development | regulation of inflammatory response | chemotaxis | negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation | ear morphogenesis | negative regulation of locomotion | positive regulation of leukocyte cell-cell adhesion | nephron tubule development | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | lens development in camera-type eye | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | mesonephric tubule development | positive regulation of gene expression | positive regulation of transcription regulatory region DNA binding | interferon-gamma production | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | response to interleukin-4 | regulation of chromatin organization
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular
