QuickView for GCG (gene)

Gene Symbol:

GCG Homo sapiens

Full name:

glucagon

Synonyms:

GLP-1, GLP1, GLP2, GRPP, glucagon, glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, preproglucagon

Genomic Location:

Chr 2: 162707634-162717003

Description:

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pat...

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The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGCA_MIR527 ,  CTAWWWATA_RSRFC4_Q2 ,  TATAAA_TATA_01 ,  CAGGTA_AREB6_01 ,  FREAC3_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  EVI1_02 ,  CHOP_01 ,  TGCTTTG_MIR330 ,  TBP_01 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-330

Cytogenetic Map:

2q24.2

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