QuickView for GDF10 (gene)

Gene Symbol:

GDF10 Homo sapiens

Full name:

growth differentiation factor 10

Synonyms:

BIP, BMP-3b, BMP3B, growth/differentiation factor 10, bone morphogenetic protein 3B, bone-inducing protein

Genomic Location:

Chr 10: 48045795-48059172

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ACTGTAG_MIR139 ,  ATACTGT_MIR144 ,  YCATTAA_UNKNOWN ,  RYTAAWNNNTGAY_UNKNOWN ,  GTTRYCATRR_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-144

Cytogenetic Map:

10q11.22

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