QuickView for GDF11 (gene)

Gene Symbol:

GDF11 Homo sapiens

Full name:

growth differentiation factor 11

Synonyms:

BMP-11, BMP11, growth/differentiation factor 11, GDF-11, bone morphogenetic protein 11

Genomic Location:

Chr 12: 54423331-54430332

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAG_MIR518A2 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-25

Cytogenetic Map:

12q13.2

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